The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Development of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34654-2 |
| _version_ | 1811230298088669184 |
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| author | Alexander Vdovin Tomas Jelinek David Zihala Tereza Sevcikova Michal Durech Hana Sahinbegovic Renata Snaurova Dhwani Radhakrishnan Marcello Turi Zuzana Chyra Tereza Popkova Ondrej Venglar Matous Hrdinka Roman Hajek Michal Simicek |
| author_facet | Alexander Vdovin Tomas Jelinek David Zihala Tereza Sevcikova Michal Durech Hana Sahinbegovic Renata Snaurova Dhwani Radhakrishnan Marcello Turi Zuzana Chyra Tereza Popkova Ondrej Venglar Matous Hrdinka Roman Hajek Michal Simicek |
| author_sort | Alexander Vdovin |
| collection | DOAJ |
| description | Development of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition. |
| first_indexed | 2024-04-12T10:28:11Z |
| format | Article |
| id | doaj.art-52b4b9da740040788e35b26372435d0d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T10:28:11Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-52b4b9da740040788e35b26372435d0d2022-12-22T03:36:56ZengNature PortfolioNature Communications2041-17232022-11-0113111710.1038/s41467-022-34654-2The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myelomaAlexander Vdovin0Tomas Jelinek1David Zihala2Tereza Sevcikova3Michal Durech4Hana Sahinbegovic5Renata Snaurova6Dhwani Radhakrishnan7Marcello Turi8Zuzana Chyra9Tereza Popkova10Ondrej Venglar11Matous Hrdinka12Roman Hajek13Michal Simicek14Department of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDepartment of Hematooncology, Faculty of Medicine, University of OstravaDevelopment of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition.https://doi.org/10.1038/s41467-022-34654-2 |
| spellingShingle | Alexander Vdovin Tomas Jelinek David Zihala Tereza Sevcikova Michal Durech Hana Sahinbegovic Renata Snaurova Dhwani Radhakrishnan Marcello Turi Zuzana Chyra Tereza Popkova Ondrej Venglar Matous Hrdinka Roman Hajek Michal Simicek The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma Nature Communications |
| title | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| title_full | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| title_fullStr | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| title_full_unstemmed | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| title_short | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| title_sort | deubiquitinase otud1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma |
| url | https://doi.org/10.1038/s41467-022-34654-2 |
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