The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Development of proteasome inhibitor resistance is a common problem in patients with multiple myeloma. Here, the authors show that deubiquitinase OTUD1 protects PRDX4 from degradation resulting in increased load of misfolded immunoglobulins sensitizing myeloma cells for proteasome inhibition.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34654-2 |