Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice
Emerging evidence shows that dietary oligosaccharides are important prebiotics that can improve intestinal flora, while dietary polyphenols can act directly on intestinal cells. However, information about their synergistic effects on gut health is still limited. In this study, alginate oligosacchari...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2023-11-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221345302300099X |
| _version_ | 1797703381669642240 |
|---|---|
| author | Jie Li Yuanjie Guo Liyuan Ma Yixiang Liu Chao Zou Huiying Kuang Bing Han Yingliang Xiao Yanbo Wang |
| author_facet | Jie Li Yuanjie Guo Liyuan Ma Yixiang Liu Chao Zou Huiying Kuang Bing Han Yingliang Xiao Yanbo Wang |
| author_sort | Jie Li |
| collection | DOAJ |
| description | Emerging evidence shows that dietary oligosaccharides are important prebiotics that can improve intestinal flora, while dietary polyphenols can act directly on intestinal cells. However, information about their synergistic effects on gut health is still limited. In this study, alginate oligosaccharide (AOS) and cyanidin-3-O-glucoside (C3G) were selected as a common marine plant oligosaccharide and terrestrial plant polyphenol, respectively, to study their effects on intestinal health. The results show that, in comparison to their individual applications, the combination of AOS and C3G (mass ratio, 3:1) displayed a stronger ability to up-regulate the expression of tight junction proteins, while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 and β-defensins were simultaneously increased in the intestinal mucus. Interestingly, the secretion of immunoglobulin A and immune-related cytokines were approximately doubled by the AOS + C3G mixture. In addition, the AOS + C3G mixture was found to be more conducive to the positive transformation of intestinal flora, which stimulated the growth of beneficial bacteria Akkermansia, Lachnospiraceae and Feacalibaculum while inhibiting the growth of harmful bacteria Helicobacter and Turicibacter. The data generated herein thus suggests that dietary oligosaccharides and dietary polyphenols may be more beneficial to intestinal health when applied in combination than their individual effects alone. |
| first_indexed | 2024-03-12T05:04:43Z |
| format | Article |
| id | doaj.art-52b56f58caf742f4bdd5931ffa980e30 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T05:04:43Z |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-52b56f58caf742f4bdd5931ffa980e302023-09-03T09:00:35ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112622762285Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in miceJie Li0Yuanjie Guo1Liyuan Ma2Yixiang Liu3Chao Zou4Huiying Kuang5Bing Han6Yingliang Xiao7Yanbo Wang8College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, China; Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing, Dalian Polytechnic University, Dalian 116034, China; Corresponding author at: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.Gaoan Public Inspection and Testing Center, Gaoan 330800, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, ChinaCollege of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, China; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaEmerging evidence shows that dietary oligosaccharides are important prebiotics that can improve intestinal flora, while dietary polyphenols can act directly on intestinal cells. However, information about their synergistic effects on gut health is still limited. In this study, alginate oligosaccharide (AOS) and cyanidin-3-O-glucoside (C3G) were selected as a common marine plant oligosaccharide and terrestrial plant polyphenol, respectively, to study their effects on intestinal health. The results show that, in comparison to their individual applications, the combination of AOS and C3G (mass ratio, 3:1) displayed a stronger ability to up-regulate the expression of tight junction proteins, while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 and β-defensins were simultaneously increased in the intestinal mucus. Interestingly, the secretion of immunoglobulin A and immune-related cytokines were approximately doubled by the AOS + C3G mixture. In addition, the AOS + C3G mixture was found to be more conducive to the positive transformation of intestinal flora, which stimulated the growth of beneficial bacteria Akkermansia, Lachnospiraceae and Feacalibaculum while inhibiting the growth of harmful bacteria Helicobacter and Turicibacter. The data generated herein thus suggests that dietary oligosaccharides and dietary polyphenols may be more beneficial to intestinal health when applied in combination than their individual effects alone.http://www.sciencedirect.com/science/article/pii/S221345302300099XAlginate oligosaccharideCyanidin-3-O-glucosidePrebioticsIntestinal barrier functionGut microbiota |
| spellingShingle | Jie Li Yuanjie Guo Liyuan Ma Yixiang Liu Chao Zou Huiying Kuang Bing Han Yingliang Xiao Yanbo Wang Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice Food Science and Human Wellness Alginate oligosaccharide Cyanidin-3-O-glucoside Prebiotics Intestinal barrier function Gut microbiota |
| title | Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice |
| title_full | Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice |
| title_fullStr | Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice |
| title_full_unstemmed | Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice |
| title_short | Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice |
| title_sort | synergistic effects of alginate oligosaccharide and cyanidin 3 o glucoside on the amelioration of intestinal barrier function in mice |
| topic | Alginate oligosaccharide Cyanidin-3-O-glucoside Prebiotics Intestinal barrier function Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S221345302300099X |
| work_keys_str_mv | AT jieli synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT yuanjieguo synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT liyuanma synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT yixiangliu synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT chaozou synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT huiyingkuang synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT binghan synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT yingliangxiao synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice AT yanbowang synergisticeffectsofalginateoligosaccharideandcyanidin3oglucosideontheameliorationofintestinalbarrierfunctioninmice |