Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination
Schistosomiasis japonica caused by the trematode flukes of <i>Schistosoma japonicum</i> was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 yea...
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MDPI AG
2022-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/3/287 |
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| author | Chao Lv Wangping Deng Liping Wang Zhiqiang Qin Xiaonong Zhou Jing Xu |
| author_facet | Chao Lv Wangping Deng Liping Wang Zhiqiang Qin Xiaonong Zhou Jing Xu |
| author_sort | Chao Lv |
| collection | DOAJ |
| description | Schistosomiasis japonica caused by the trematode flukes of <i>Schistosoma japonicum</i> was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 years of continuous control campaigns. Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplification of promising genes of the schistosome genome may pick up the baton to assist the eventual aim of elimination. In this article, we reviewed the developed molecular methods for detecting <i>S. japonicum</i> infection and their application in schistosomiasis japonica diagnosis. Concurrently, we also analyzed the chances and challenges of molecular tools to the field application process in China. |
| first_indexed | 2024-03-09T13:02:40Z |
| format | Article |
| id | doaj.art-52b6e2b9414c45588a82c96808ae30fb |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T13:02:40Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-52b6e2b9414c45588a82c96808ae30fb2023-11-30T21:51:57ZengMDPI AGPathogens2076-08172022-02-0111328710.3390/pathogens11030287Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards EliminationChao Lv0Wangping Deng1Liping Wang2Zhiqiang Qin3Xiaonong Zhou4Jing Xu5National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, ChinaJiading District Center for Disease Control and Prevention, Shanghai 200025, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, ChinaSchistosomiasis japonica caused by the trematode flukes of <i>Schistosoma japonicum</i> was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 years of continuous control campaigns. Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplification of promising genes of the schistosome genome may pick up the baton to assist the eventual aim of elimination. In this article, we reviewed the developed molecular methods for detecting <i>S. japonicum</i> infection and their application in schistosomiasis japonica diagnosis. Concurrently, we also analyzed the chances and challenges of molecular tools to the field application process in China.https://www.mdpi.com/2076-0817/11/3/287schistosomiasis japonicaeliminationdiagnostic toolsmolecular techniques |
| spellingShingle | Chao Lv Wangping Deng Liping Wang Zhiqiang Qin Xiaonong Zhou Jing Xu Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination Pathogens schistosomiasis japonica elimination diagnostic tools molecular techniques |
| title | Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination |
| title_full | Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination |
| title_fullStr | Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination |
| title_full_unstemmed | Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination |
| title_short | Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination |
| title_sort | molecular techniques as alternatives of diagnostic tools in china as schistosomiasis moving towards elimination |
| topic | schistosomiasis japonica elimination diagnostic tools molecular techniques |
| url | https://www.mdpi.com/2076-0817/11/3/287 |
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