Voluntary exercise and cardiac remodeling in a myocardial infarction model
We investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI), exercise + sham (Ex-Sh), and exercise + MI (Ex-MI)...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2020-06-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2020-0109 |
| _version_ | 1818737899372281856 |
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| author | Shahi Hamad Al Kadoguchi Tomoyasu Shimada Kazunori Fukao Kosuke Matsushita Satoshi Aikawa Tatsuro Ouchi Shohei Shiozawa Tomoyuki Takahashi Shuhei Sato-Okabayashi Yayoi Akita Koji Isoda Kikuo Miyazaki Tetsuro Daida Hiroyuki |
| author_facet | Shahi Hamad Al Kadoguchi Tomoyasu Shimada Kazunori Fukao Kosuke Matsushita Satoshi Aikawa Tatsuro Ouchi Shohei Shiozawa Tomoyuki Takahashi Shuhei Sato-Okabayashi Yayoi Akita Koji Isoda Kikuo Miyazaki Tetsuro Daida Hiroyuki |
| author_sort | Shahi Hamad Al |
| collection | DOAJ |
| description | We investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI), exercise + sham (Ex-Sh), and exercise + MI (Ex-MI). MI induction was performed by ligation of the left coronary artery. Exercise consisting of voluntary wheel running started after the operation and continued for 4 weeks. The Ex-MI mice had significantly increased cardiac function compared with the Sed-MI mice. The Ex-MI mice showed significantly reduced expression levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-10 in the infarcted area of the left ventricle compared with the Sed-MI mice. In the Ex-MI mice, the expression levels of fibrosis-related genes including collagen I and III were decreased compared to the Sed-MI mice, and the expression levels of IL-1β, IL-6, follistatin-like 1, fibroblast growth factor 21, and mitochondrial function-related genes were significantly elevated in skeletal muscle compared with the Sed mice. The plasma levels of IL-6 were also significantly elevated in the Ex-MI group compared with the Sed-MI groups. These findings suggest that voluntary exercise after MI may improve in cardiac remodeling associated with anti-inflammatory effects in the myocardium and myokine production in the skeletal muscles. |
| first_indexed | 2024-12-18T01:00:22Z |
| format | Article |
| id | doaj.art-52b70cc9b1d747a89dd60eeb5cea6cd6 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-18T01:00:22Z |
| publishDate | 2020-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-52b70cc9b1d747a89dd60eeb5cea6cd62022-12-21T21:26:24ZengDe GruyterOpen Medicine2391-54632020-06-0115154555510.1515/med-2020-0109med-2020-0109Voluntary exercise and cardiac remodeling in a myocardial infarction modelShahi Hamad Al0Kadoguchi Tomoyasu1Shimada Kazunori2Fukao Kosuke3Matsushita Satoshi4Aikawa Tatsuro5Ouchi Shohei6Shiozawa Tomoyuki7Takahashi Shuhei8Sato-Okabayashi Yayoi9Akita Koji10Isoda Kikuo11Miyazaki Tetsuro12Daida Hiroyuki13Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanWe investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI), exercise + sham (Ex-Sh), and exercise + MI (Ex-MI). MI induction was performed by ligation of the left coronary artery. Exercise consisting of voluntary wheel running started after the operation and continued for 4 weeks. The Ex-MI mice had significantly increased cardiac function compared with the Sed-MI mice. The Ex-MI mice showed significantly reduced expression levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-10 in the infarcted area of the left ventricle compared with the Sed-MI mice. In the Ex-MI mice, the expression levels of fibrosis-related genes including collagen I and III were decreased compared to the Sed-MI mice, and the expression levels of IL-1β, IL-6, follistatin-like 1, fibroblast growth factor 21, and mitochondrial function-related genes were significantly elevated in skeletal muscle compared with the Sed mice. The plasma levels of IL-6 were also significantly elevated in the Ex-MI group compared with the Sed-MI groups. These findings suggest that voluntary exercise after MI may improve in cardiac remodeling associated with anti-inflammatory effects in the myocardium and myokine production in the skeletal muscles.https://doi.org/10.1515/med-2020-0109voluntary exercisemyocardial infarctioncardiac remodelinginflammationmyokine |
| spellingShingle | Shahi Hamad Al Kadoguchi Tomoyasu Shimada Kazunori Fukao Kosuke Matsushita Satoshi Aikawa Tatsuro Ouchi Shohei Shiozawa Tomoyuki Takahashi Shuhei Sato-Okabayashi Yayoi Akita Koji Isoda Kikuo Miyazaki Tetsuro Daida Hiroyuki Voluntary exercise and cardiac remodeling in a myocardial infarction model Open Medicine voluntary exercise myocardial infarction cardiac remodeling inflammation myokine |
| title | Voluntary exercise and cardiac remodeling in a myocardial infarction model |
| title_full | Voluntary exercise and cardiac remodeling in a myocardial infarction model |
| title_fullStr | Voluntary exercise and cardiac remodeling in a myocardial infarction model |
| title_full_unstemmed | Voluntary exercise and cardiac remodeling in a myocardial infarction model |
| title_short | Voluntary exercise and cardiac remodeling in a myocardial infarction model |
| title_sort | voluntary exercise and cardiac remodeling in a myocardial infarction model |
| topic | voluntary exercise myocardial infarction cardiac remodeling inflammation myokine |
| url | https://doi.org/10.1515/med-2020-0109 |
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