ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

Abstract Background During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine kinase ErbB4 is requi...

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Bibliographic Details
Main Authors: Michelle M. Williams, David B. Vaught, Meghan Morrison Joly, Donna J. Hicks, Violeta Sanchez, Philip Owens, Bushra Rahman, David L. Elion, Justin M. Balko, Rebecca S. Cook
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Breast Cancer Research
Subjects:
ErbB3
ErbB4
STAT5A
Jak2
Lactation
Mammary gland development
Online Access:http://link.springer.com/article/10.1186/s13058-017-0893-7

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