The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma
Purpose Radiological imaging in Dedifferentiated liposarcoma (DDLPS) often shows the coexistence of fatty and non-fatty solid components; however, it has been shown that when fatty components were not identified on magnetic resonance imaging (MRI), the diagnosis of DDLPS would not have been diagnose...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/10225536231151519 |
| _version_ | 1811173531379040256 |
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| author | Keisuke Yoshida Tomoki Nakamura Koichi Nakamura Yumi Matsuyama Tomohito Hagi Kunihiro Asanuma Akihiro Sudo |
| author_facet | Keisuke Yoshida Tomoki Nakamura Koichi Nakamura Yumi Matsuyama Tomohito Hagi Kunihiro Asanuma Akihiro Sudo |
| author_sort | Keisuke Yoshida |
| collection | DOAJ |
| description | Purpose Radiological imaging in Dedifferentiated liposarcoma (DDLPS) often shows the coexistence of fatty and non-fatty solid components; however, it has been shown that when fatty components were not identified on magnetic resonance imaging (MRI), the diagnosis of DDLPS would not have been diagnosed if immunohistochemical (IHC) staining had not been performed. The aim of this study was to investigate the pattern of MRI and relationship between MRI and IHC findings in DDLPS. Methods We retrospectively reviewed the cases of 25 patients with DDLPS. To identify the MRI spectrum of DDLPS, tumors were classified into the following four categories based on MRI findings: I = a well-defined fatty mass and juxtaposed well-defined non-fatty mass, II = a non-fatty component within a predominantly fatty mass, III = a focal fatty component within a large non-fatty mass, and IV = a non-fatty mass with atypical MRI findings. IHC staining for CDK4, MDM2, and p16 were evaluated. Results Category IV tumor was the most common tumor in this population. Of the 22 patients who underwent IHC staining, MDM2, CDK4, and p16 were positive in 21, 20, and 19 patients, respectively. MDM2 was positive in all 11 patients with category IV tumors; CDK4 and p 16 were positive in 10 and eight patients, respectively. There was no difference of survival between the patients with category I, II and III and category IV. Conclusions DDLPS without fatty components on MRI scans was mostly found. We recommend IHC staining to screen for DDLPS even if the tumors in STS cases have a non-fatty component. |
| first_indexed | 2024-04-10T17:48:32Z |
| format | Article |
| id | doaj.art-52bb1d739e864d46ad6ee99ddb0444dc |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-04-10T17:48:32Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-52bb1d739e864d46ad6ee99ddb0444dc2023-02-03T01:33:20ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902023-01-013110.1177/10225536231151519The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcomaKeisuke YoshidaTomoki NakamuraKoichi NakamuraYumi MatsuyamaTomohito HagiKunihiro AsanumaAkihiro SudoPurpose Radiological imaging in Dedifferentiated liposarcoma (DDLPS) often shows the coexistence of fatty and non-fatty solid components; however, it has been shown that when fatty components were not identified on magnetic resonance imaging (MRI), the diagnosis of DDLPS would not have been diagnosed if immunohistochemical (IHC) staining had not been performed. The aim of this study was to investigate the pattern of MRI and relationship between MRI and IHC findings in DDLPS. Methods We retrospectively reviewed the cases of 25 patients with DDLPS. To identify the MRI spectrum of DDLPS, tumors were classified into the following four categories based on MRI findings: I = a well-defined fatty mass and juxtaposed well-defined non-fatty mass, II = a non-fatty component within a predominantly fatty mass, III = a focal fatty component within a large non-fatty mass, and IV = a non-fatty mass with atypical MRI findings. IHC staining for CDK4, MDM2, and p16 were evaluated. Results Category IV tumor was the most common tumor in this population. Of the 22 patients who underwent IHC staining, MDM2, CDK4, and p16 were positive in 21, 20, and 19 patients, respectively. MDM2 was positive in all 11 patients with category IV tumors; CDK4 and p 16 were positive in 10 and eight patients, respectively. There was no difference of survival between the patients with category I, II and III and category IV. Conclusions DDLPS without fatty components on MRI scans was mostly found. We recommend IHC staining to screen for DDLPS even if the tumors in STS cases have a non-fatty component.https://doi.org/10.1177/10225536231151519 |
| spellingShingle | Keisuke Yoshida Tomoki Nakamura Koichi Nakamura Yumi Matsuyama Tomohito Hagi Kunihiro Asanuma Akihiro Sudo The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma Journal of Orthopaedic Surgery |
| title | The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma |
| title_full | The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma |
| title_fullStr | The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma |
| title_full_unstemmed | The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma |
| title_short | The Characteristics of magnetic resonance imaging and immunohistochemical findings in de-differentiated liposarcoma |
| title_sort | characteristics of magnetic resonance imaging and immunohistochemical findings in de differentiated liposarcoma |
| url | https://doi.org/10.1177/10225536231151519 |
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