Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene transcription. We created a PI polyamide targeting human TGF-β1 (hTGF-β1). To develop this PI polyamide targeting hTGF-&am...

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Bibliographic Details
Main Authors:	Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi, Morito Endo, Masanori Abe
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Molecules
Subjects:	human TGF-β1 pyrrole-imidazole polyamide renal disease marmoset
Online Access:	https://www.mdpi.com/1420-3049/24/17/3178

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