Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up
AIM: To compare the corneal outcome in Fuchs' endothelial dystrophy (FED) patients between femtosecond laser-assisted cataract surgery (FLACS) and conventional phaco surgery (CPS). METHODS: This was a randomized controlled study comparing one eye surgery by FLACS and the contralateral eye opera...
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-05-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2021/5/20210507.pdf |
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| author | Therese Krarup Kathrine Rose Aurore Marie-Laurence Akpé Mensah Morten la Cour Lars Morten Holm |
| author_facet | Therese Krarup Kathrine Rose Aurore Marie-Laurence Akpé Mensah Morten la Cour Lars Morten Holm |
| author_sort | Therese Krarup |
| collection | DOAJ |
| description | AIM: To compare the corneal outcome in Fuchs' endothelial dystrophy (FED) patients between femtosecond laser-assisted cataract surgery (FLACS) and conventional phaco surgery (CPS). METHODS: This was a randomized controlled study comparing one eye surgery by FLACS and the contralateral eye operated by CPS (stop and chop technique) in FED patients. Central corneal thickness, corneal light backscatter, corneal densitometry, and central corneal endothelial cell count and hexagonality (noncontact endothelial cell microscope), and corrected distance visual acuity (CDVA) were assessed preoperatively and at day 1, 40, and 180 postoperatively. RESULTS: Totally 31 patients (16 women) were included. At day 40 postoperatively, the mean endothelial cell loss (ECL) was 23.67% by FLACS and 17.30% by CPS (P=0.53). At day 180 postoperatively, ECL was 25.58% in FLACS and 21.32% in CPS (P=0.69). Densitometry data in all layers and all annuli from anterior layer to posterior layer in annuli 0-2, 2-6, 6-10 and 10-12, total densitometry with all layers and all annuli was performed. A significant difference was found in 6-10 (posterior layer) at day 1 with -1.42 grayscale units (GSU; 95%CI: -2.66 to -0.19, P=0.02). In 10-12 (anterior layer, central layer and all layers) at day 40 were significant different with 7.7 (95%CI: 1.89 to 13.50, P=0.009), 3.97 (95%CI: 0.23 to 7.71, P=0.03), 4.73 GSU (95%CI: 0.71 to 8.75, P=0.02), respectively. In the remaining parameters we found no difference between the two groups (P>0.05). Three CPS eyes suffered from corneal decompensation. CONCLUSION: There is no significant difference in corneal outcome between FLACS and CPS. Endothelial cell density and pentacam corneal outcome may be inadequate as outcome parameters in FED patients. |
| first_indexed | 2024-12-24T05:39:45Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-24T05:39:45Z |
| publishDate | 2021-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj.art-52bc8eae89194497b629c0063b0061452022-12-21T17:12:51ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982021-05-0114568469210.18240/ijo.2021.05.0720210507Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow upTherese Krarup0Kathrine Rose1Aurore Marie-Laurence Akpé Mensah2Morten la Cour3Lars Morten Holm4Therese Krarup. Department of Ophthalmology Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23, Glostrup 2600, Denmark. theresekrarup@gmail.comDepartment of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23, Glostrup 2600, DenmarkDepartment of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23, Glostrup 2600, DenmarkDepartment of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23, Glostrup 2600, DenmarkDepartment of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23, Glostrup 2600, DenmarkAIM: To compare the corneal outcome in Fuchs' endothelial dystrophy (FED) patients between femtosecond laser-assisted cataract surgery (FLACS) and conventional phaco surgery (CPS). METHODS: This was a randomized controlled study comparing one eye surgery by FLACS and the contralateral eye operated by CPS (stop and chop technique) in FED patients. Central corneal thickness, corneal light backscatter, corneal densitometry, and central corneal endothelial cell count and hexagonality (noncontact endothelial cell microscope), and corrected distance visual acuity (CDVA) were assessed preoperatively and at day 1, 40, and 180 postoperatively. RESULTS: Totally 31 patients (16 women) were included. At day 40 postoperatively, the mean endothelial cell loss (ECL) was 23.67% by FLACS and 17.30% by CPS (P=0.53). At day 180 postoperatively, ECL was 25.58% in FLACS and 21.32% in CPS (P=0.69). Densitometry data in all layers and all annuli from anterior layer to posterior layer in annuli 0-2, 2-6, 6-10 and 10-12, total densitometry with all layers and all annuli was performed. A significant difference was found in 6-10 (posterior layer) at day 1 with -1.42 grayscale units (GSU; 95%CI: -2.66 to -0.19, P=0.02). In 10-12 (anterior layer, central layer and all layers) at day 40 were significant different with 7.7 (95%CI: 1.89 to 13.50, P=0.009), 3.97 (95%CI: 0.23 to 7.71, P=0.03), 4.73 GSU (95%CI: 0.71 to 8.75, P=0.02), respectively. In the remaining parameters we found no difference between the two groups (P>0.05). Three CPS eyes suffered from corneal decompensation. CONCLUSION: There is no significant difference in corneal outcome between FLACS and CPS. Endothelial cell density and pentacam corneal outcome may be inadequate as outcome parameters in FED patients.http://ies.ijo.cn/en_publish/2021/5/20210507.pdfcataract surgeryfemtosecond-assisted cataract surgerycorneal endothelial cell losscentral corneal thicknesspentacamfuchs' endothelial dystrophy |
| spellingShingle | Therese Krarup Kathrine Rose Aurore Marie-Laurence Akpé Mensah Morten la Cour Lars Morten Holm Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up International Journal of Ophthalmology cataract surgery femtosecond-assisted cataract surgery corneal endothelial cell loss central corneal thickness pentacam fuchs' endothelial dystrophy |
| title | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up |
| title_full | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up |
| title_fullStr | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up |
| title_full_unstemmed | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up |
| title_short | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’ endothelial dystrophy patients: a randomized pilot study with 6mo follow up |
| title_sort | comparing corneal outcome between femtosecond laser assisted cataract surgery and conventional phaco surgery in fuchs endothelial dystrophy patients a randomized pilot study with 6mo follow up |
| topic | cataract surgery femtosecond-assisted cataract surgery corneal endothelial cell loss central corneal thickness pentacam fuchs' endothelial dystrophy |
| url | http://ies.ijo.cn/en_publish/2021/5/20210507.pdf |
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