A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining
Background and Introduction: Acute Organophosphorus poisoning (OP) is important cause of morbidity and mortality in India. In medical emergency 10% of admissions are due to poisoning and organophosphorus poisoning contributes to nearly 50% ofcases1,2,3.The objective of the study...
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| Format: | Article |
| Language: | English |
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BKL Walawalkar Rural Medical College & Hospital
2020-07-01
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| Series: | Walawalkar International Medical Journal |
| Subjects: | |
| Online Access: | http://www.wimjournal.com/html/journal/images/7a6.pdf |
| _version_ | 1819211340548407296 |
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| author | Sagar Subhash Nanaware Sanjay M Suvarna Patil Jagannath Sarangi Eknath Bamane Janvi Despande Vikas Deokar |
| author_facet | Sagar Subhash Nanaware Sanjay M Suvarna Patil Jagannath Sarangi Eknath Bamane Janvi Despande Vikas Deokar |
| author_sort | Sagar Subhash Nanaware |
| collection | DOAJ |
| description | Background and Introduction:
Acute Organophosphorus poisoning (OP) is important cause of morbidity and mortality in India. In medical emergency 10% of admissions are due to poisoning and organophosphorus poisoning contributes to nearly 50% ofcases1,2,3.The objective of the study is to study the levels of pseudocholinesterase in serum as a diagnostic aid in patients with suspected organophosphorus poisoning and to predict the prognosis based on pseudocholinesterase activity.
Materials and Methods:
Informed consent was taken from 50 patients suspected of organophosphorus poisoning and admitted to Medical Emergency Ward.Pseudocholinesterase levels were estimated by S-butyrylthiocholine iodide method using dibucaine as inhibitor. Serum levels of pseudocholinesteraselevels of patients were examined on Day 1, Day 2, Day 3 and Day 6 of admission.
Result:
Patients who survived had increasing levels of pseudocholinesterase activity of 3.56% on 2nd day and further rise of 4.48% on 3rd day and a rise of 6.88% on 6th day. In patients who expired,the enzyme activity had reduced by 4.6%on Day 2 and a raise of 11% on Day 3 and a fall of 5.5% on Day 6. It was observed that the enzyme activity in patients those survived has increased on successive days indicating a better prognosis whereas the enzyme activity in patients those expired was falling except for the Day 3 where a raise of 11% was noticed. This may be probably due to the treatment given to the patients,which has caused a transient raise in enzyme levels.
Conclusion:
In early stages of poisoning,determining pseudocholinesterase activity isreliable diagnostic test. Mean pseudocholinesterase activity in patients who survived was above 4300 U/L and the levels had increased in the successive days above 5400 U/L, which indicated better prognosis. In the patients who expired the pseudocholinesterase activity was around 4300 U/L and was falling except for the Day 3. This point out that raise in enzyme levels is directly proportional to better prognosis. |
| first_indexed | 2024-12-23T06:25:31Z |
| format | Article |
| id | doaj.art-52bec3ed70214d5b9b2f46fcabf71d64 |
| institution | Directory Open Access Journal |
| issn | 2395-0684 2395-0684 |
| language | English |
| last_indexed | 2024-12-23T06:25:31Z |
| publishDate | 2020-07-01 |
| publisher | BKL Walawalkar Rural Medical College & Hospital |
| record_format | Article |
| series | Walawalkar International Medical Journal |
| spelling | doaj.art-52bec3ed70214d5b9b2f46fcabf71d642022-12-21T17:57:05ZengBKL Walawalkar Rural Medical College & HospitalWalawalkar International Medical Journal2395-06842395-06842020-07-01713844A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus PoisoiningSagar Subhash Nanaware0Sanjay M1Suvarna Patil2Jagannath Sarangi3Eknath Bamane4Janvi Despande5Vikas Deokar6Assistant Professor of General Medicine, BKL Walawalkar Rural Medical College & Hospital, Sawarde, Chiplun, Dist – Ratnagiri, Maharashtra, IndiaAssistant Professor of General Medicine,Saptagiri Institute of Medical Sciences, Bengaluru, KarnatakaAssociate Professorof General Medicine,BKL Walawalkar Rural Medical College & Hospital, Sawarde, Chiplun, Dist – Ratnagiri, Maharashtra, IndiaAssociate Professorof General Medicine, MKCG Medical College and Hospital, Berhampur, OrissaAssistant Professor of General Medicine, BKL Walawalkar Rural Medical College & Hospital, Sawarde, Chiplun, Dist – Ratnagiri, Maharashtra, India Professor of General Medicine, BKL Walawalkar Rural Medical College & Hospital, Sawarde, Chiplun, Dist – Ratnagiri, Maharashtra, IndiaSenior Resident in General Medicine,BKL Walawalkar Rural Medical College & Hospital, Sawarde, Chiplun, Dist – Ratnagiri, Maharashtra, IndiaBackground and Introduction: Acute Organophosphorus poisoning (OP) is important cause of morbidity and mortality in India. In medical emergency 10% of admissions are due to poisoning and organophosphorus poisoning contributes to nearly 50% ofcases1,2,3.The objective of the study is to study the levels of pseudocholinesterase in serum as a diagnostic aid in patients with suspected organophosphorus poisoning and to predict the prognosis based on pseudocholinesterase activity. Materials and Methods: Informed consent was taken from 50 patients suspected of organophosphorus poisoning and admitted to Medical Emergency Ward.Pseudocholinesterase levels were estimated by S-butyrylthiocholine iodide method using dibucaine as inhibitor. Serum levels of pseudocholinesteraselevels of patients were examined on Day 1, Day 2, Day 3 and Day 6 of admission. Result: Patients who survived had increasing levels of pseudocholinesterase activity of 3.56% on 2nd day and further rise of 4.48% on 3rd day and a rise of 6.88% on 6th day. In patients who expired,the enzyme activity had reduced by 4.6%on Day 2 and a raise of 11% on Day 3 and a fall of 5.5% on Day 6. It was observed that the enzyme activity in patients those survived has increased on successive days indicating a better prognosis whereas the enzyme activity in patients those expired was falling except for the Day 3 where a raise of 11% was noticed. This may be probably due to the treatment given to the patients,which has caused a transient raise in enzyme levels. Conclusion: In early stages of poisoning,determining pseudocholinesterase activity isreliable diagnostic test. Mean pseudocholinesterase activity in patients who survived was above 4300 U/L and the levels had increased in the successive days above 5400 U/L, which indicated better prognosis. In the patients who expired the pseudocholinesterase activity was around 4300 U/L and was falling except for the Day 3. This point out that raise in enzyme levels is directly proportional to better prognosis.http://www.wimjournal.com/html/journal/images/7a6.pdforganophosphorus poisoningpseudocholinesterase |
| spellingShingle | Sagar Subhash Nanaware Sanjay M Suvarna Patil Jagannath Sarangi Eknath Bamane Janvi Despande Vikas Deokar A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining Walawalkar International Medical Journal organophosphorus poisoning pseudocholinesterase |
| title | A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining |
| title_full | A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining |
| title_fullStr | A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining |
| title_full_unstemmed | A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining |
| title_short | A Study of Serum Pseudocholinesterase Levels inAcute Organophosphorus Poisoining |
| title_sort | study of serum pseudocholinesterase levels inacute organophosphorus poisoining |
| topic | organophosphorus poisoning pseudocholinesterase |
| url | http://www.wimjournal.com/html/journal/images/7a6.pdf |
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