Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid
Abstract Background Ovarian strumal carcinoid is an extremely rare ovarian malignant tumor with limited data on clinical characteristics and survival outcomes. Methods A retrospective study of 119 patients was conducted, including 98 cases identified from literature review, and their clinical charac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10167-5 |
| _version_ | 1797991824505176064 |
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| author | Sijian Li Xiaoxue Wang Xiaolong Sui Xinyue Zhang Min Yin Jiaxin Yang |
| author_facet | Sijian Li Xiaoxue Wang Xiaolong Sui Xinyue Zhang Min Yin Jiaxin Yang |
| author_sort | Sijian Li |
| collection | DOAJ |
| description | Abstract Background Ovarian strumal carcinoid is an extremely rare ovarian malignant tumor with limited data on clinical characteristics and survival outcomes. Methods A retrospective study of 119 patients was conducted, including 98 cases identified from literature review, and their clinical characteristics were investigated. The overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and potential prognostic factors of these patients were also evaluated. Results Lesions of 115 cases were confined to the ovarian while four patients presented with extra-ovarian disease upon initial diagnosis. Surgical treatment options performed in this cohort varied, 5.0% received ovarian cystectomy, 36.1% received unilateral salpingo-oophorectomy (USO), 7.6% received bilateral salpingo-oophorectomy (BSO), 42.0% received hysterectomy with BSO, and 8.4% underwent debulking surgery. Moreover, one patient did not undergo any surgery. No postoperative adjuvant therapy was administered in 89.9% patients, while 7.6% and 2.5% received adjuvant radiotherapy and chemotherapy, of which two patients received combined radiation and chemotherapy. At the final follow-up, 89.1% patients showed no evidence of the disease, and 5.0% were alive with the disease. Only seven deaths occurred, with two attributed to the tumor. The 5-year, 10-year, and 20-year OS rates were 96.0%, 85.0%, and 85.0%, respectively, with a 15-year recurrence rate of 4.4%. The 5-year and 20-year DSS rate were 98.5% and 95.9%. Multivariate Cox regression showed age ≥ 55 years was the only risk factor associated with the OS (P = 0.014, OR 7.988; 95% CI 1.519 – 42.004). However, the univariate and multivariate Cox regression showed no potential risk factor for RFS and DSS. Conclusion Patients with ovarian strumal carcinoid have an excellent prognosis irrespective of the surgical option. Conservative surgery especially USO with individualized adjuvant therapy is recommended. |
| first_indexed | 2024-04-11T08:57:08Z |
| format | Article |
| id | doaj.art-52c0bee72bdb4db481564d99e9e40754 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T08:57:08Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-52c0bee72bdb4db481564d99e9e407542022-12-22T04:33:09ZengBMCBMC Cancer1471-24072022-10-012211910.1186/s12885-022-10167-5Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoidSijian Li0Xiaoxue Wang1Xiaolong Sui2Xinyue Zhang3Min Yin4Jiaxin Yang5National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeNational Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pathology, The Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityNational Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeNational Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeNational Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeAbstract Background Ovarian strumal carcinoid is an extremely rare ovarian malignant tumor with limited data on clinical characteristics and survival outcomes. Methods A retrospective study of 119 patients was conducted, including 98 cases identified from literature review, and their clinical characteristics were investigated. The overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and potential prognostic factors of these patients were also evaluated. Results Lesions of 115 cases were confined to the ovarian while four patients presented with extra-ovarian disease upon initial diagnosis. Surgical treatment options performed in this cohort varied, 5.0% received ovarian cystectomy, 36.1% received unilateral salpingo-oophorectomy (USO), 7.6% received bilateral salpingo-oophorectomy (BSO), 42.0% received hysterectomy with BSO, and 8.4% underwent debulking surgery. Moreover, one patient did not undergo any surgery. No postoperative adjuvant therapy was administered in 89.9% patients, while 7.6% and 2.5% received adjuvant radiotherapy and chemotherapy, of which two patients received combined radiation and chemotherapy. At the final follow-up, 89.1% patients showed no evidence of the disease, and 5.0% were alive with the disease. Only seven deaths occurred, with two attributed to the tumor. The 5-year, 10-year, and 20-year OS rates were 96.0%, 85.0%, and 85.0%, respectively, with a 15-year recurrence rate of 4.4%. The 5-year and 20-year DSS rate were 98.5% and 95.9%. Multivariate Cox regression showed age ≥ 55 years was the only risk factor associated with the OS (P = 0.014, OR 7.988; 95% CI 1.519 – 42.004). However, the univariate and multivariate Cox regression showed no potential risk factor for RFS and DSS. Conclusion Patients with ovarian strumal carcinoid have an excellent prognosis irrespective of the surgical option. Conservative surgery especially USO with individualized adjuvant therapy is recommended.https://doi.org/10.1186/s12885-022-10167-5Strumal carcinoidOvarian carcinoidClinical characteristicsTreatmentSurvival outcomes |
| spellingShingle | Sijian Li Xiaoxue Wang Xiaolong Sui Xinyue Zhang Min Yin Jiaxin Yang Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid BMC Cancer Strumal carcinoid Ovarian carcinoid Clinical characteristics Treatment Survival outcomes |
| title | Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| title_full | Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| title_fullStr | Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| title_full_unstemmed | Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| title_short | Clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| title_sort | clinical characteristics and survival outcomes in patients with ovarian strumal carcinoid |
| topic | Strumal carcinoid Ovarian carcinoid Clinical characteristics Treatment Survival outcomes |
| url | https://doi.org/10.1186/s12885-022-10167-5 |
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