Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene
Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/7911 |
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| author | Ruslan Kashapov Yuliya Razuvayeva Nadezda Kashapova Albina Ziganshina Vadim Salnikov Anastasiia Sapunova Alexandra Voloshina Lucia Zakharova |
| author_facet | Ruslan Kashapov Yuliya Razuvayeva Nadezda Kashapova Albina Ziganshina Vadim Salnikov Anastasiia Sapunova Alexandra Voloshina Lucia Zakharova |
| author_sort | Ruslan Kashapov |
| collection | DOAJ |
| description | Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation of nanosized particles through the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family was reported for the first time. This self-assembly into nanoparticles was realized using cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are able to bind various hydrophobic (quercetin, oleic acid) and hydrophilic (doxorubicin) drugs, as a result of which their cytotoxic properties are enhanced. This work demonstrates that intermolecular interactions between flexible RNA and rigid calixarene is a promising route to bottom-up assembly of novel supramolecular soft matter, expanding the design possibilities of nanoscale drug carriers. |
| first_indexed | 2024-03-11T04:17:04Z |
| format | Article |
| id | doaj.art-52c24534c8db48eaa5c9dc99553c7c7f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:17:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-52c24534c8db48eaa5c9dc99553c7c7f2023-11-17T23:02:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249791110.3390/ijms24097911Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with CalixareneRuslan Kashapov0Yuliya Razuvayeva1Nadezda Kashapova2Albina Ziganshina3Vadim Salnikov4Anastasiia Sapunova5Alexandra Voloshina6Lucia Zakharova7Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky Str., 420111 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, RussiaSupramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation of nanosized particles through the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family was reported for the first time. This self-assembly into nanoparticles was realized using cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are able to bind various hydrophobic (quercetin, oleic acid) and hydrophilic (doxorubicin) drugs, as a result of which their cytotoxic properties are enhanced. This work demonstrates that intermolecular interactions between flexible RNA and rigid calixarene is a promising route to bottom-up assembly of novel supramolecular soft matter, expanding the design possibilities of nanoscale drug carriers.https://www.mdpi.com/1422-0067/24/9/7911resorcinareneRNAsupramolecular self-assemblydrug deliveryM HeLaChang liver |
| spellingShingle | Ruslan Kashapov Yuliya Razuvayeva Nadezda Kashapova Albina Ziganshina Vadim Salnikov Anastasiia Sapunova Alexandra Voloshina Lucia Zakharova Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene International Journal of Molecular Sciences resorcinarene RNA supramolecular self-assembly drug delivery M HeLa Chang liver |
| title | Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene |
| title_full | Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene |
| title_fullStr | Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene |
| title_full_unstemmed | Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene |
| title_short | Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene |
| title_sort | emergence of nanoscale drug carriers through supramolecular self assembly of rna with calixarene |
| topic | resorcinarene RNA supramolecular self-assembly drug delivery M HeLa Chang liver |
| url | https://www.mdpi.com/1422-0067/24/9/7911 |
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