Antiplatelets and Vascular Dementia: A Systematic Review
Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9780067 |
| _version_ | 1811181831694843904 |
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| author | Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla |
| author_facet | Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla |
| author_sort | Peter Alexander |
| collection | DOAJ |
| description | Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology should have vascular risk factors, particularly hypertension, examined and treated. While these strategies may be more effective at avoiding dementia than at ameliorating it, there is a compelling case for intensive secondary stroke prevention in these patients. Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death. In general, most physicians follow recommendations for secondary stroke prevention in patients with VD, which can be accomplished by the use of antithrombotic medicines such as antiplatelets (aspirin, clopidogrel, ticlopidine, cilostazol, etc.). In individuals with a high risk of atherosclerosis and those with documented symptomatic cerebrovascular illness, antiplatelets treatment lowers the risk of stroke. While this therapy strategy of prevention and rigorous risk management has a compelling justification, there is only limited and indirect data to support it. The following systematic review examines the role of antiplatelets in the management of vascular dementia in published clinical trials and studies and comments on the current evidence available to support their use and highlights the need for further study. |
| first_indexed | 2024-04-11T09:23:32Z |
| format | Article |
| id | doaj.art-52c65868e681495986519ade75262a3f |
| institution | Directory Open Access Journal |
| issn | 2090-2212 |
| language | English |
| last_indexed | 2024-04-11T09:23:32Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj.art-52c65868e681495986519ade75262a3f2022-12-22T04:32:06ZengHindawi LimitedJournal of Aging Research2090-22122022-01-01202210.1155/2022/9780067Antiplatelets and Vascular Dementia: A Systematic ReviewPeter Alexander0Shakthi Visagan1Sara Jawhar2Amogh Kare3Noor Issa4Reem Issa5Abbas Jawhar6Sneha Thomas7Vasavi Gorantla8Department of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Anatomical SciencesDepartment of Internal MedicineDepartment of Anatomical SciencesVascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology should have vascular risk factors, particularly hypertension, examined and treated. While these strategies may be more effective at avoiding dementia than at ameliorating it, there is a compelling case for intensive secondary stroke prevention in these patients. Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death. In general, most physicians follow recommendations for secondary stroke prevention in patients with VD, which can be accomplished by the use of antithrombotic medicines such as antiplatelets (aspirin, clopidogrel, ticlopidine, cilostazol, etc.). In individuals with a high risk of atherosclerosis and those with documented symptomatic cerebrovascular illness, antiplatelets treatment lowers the risk of stroke. While this therapy strategy of prevention and rigorous risk management has a compelling justification, there is only limited and indirect data to support it. The following systematic review examines the role of antiplatelets in the management of vascular dementia in published clinical trials and studies and comments on the current evidence available to support their use and highlights the need for further study.http://dx.doi.org/10.1155/2022/9780067 |
| spellingShingle | Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla Antiplatelets and Vascular Dementia: A Systematic Review Journal of Aging Research |
| title | Antiplatelets and Vascular Dementia: A Systematic Review |
| title_full | Antiplatelets and Vascular Dementia: A Systematic Review |
| title_fullStr | Antiplatelets and Vascular Dementia: A Systematic Review |
| title_full_unstemmed | Antiplatelets and Vascular Dementia: A Systematic Review |
| title_short | Antiplatelets and Vascular Dementia: A Systematic Review |
| title_sort | antiplatelets and vascular dementia a systematic review |
| url | http://dx.doi.org/10.1155/2022/9780067 |
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