Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues
A synthetic route for adhesive core-multishell (CMS) nanocarriers for application to the oral mucosa was established using mussel-inspired catechol moieties. The three CMS nanocarriers with 8%, 13%, and 20% catechol functionalization were evaluated for loading capacity using Nile red, showing an ove...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/940 |
| _version_ | 1797496709684658176 |
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| author | Keerthana Rajes Peer Nölte Cynthia V. Yapto Kerstin Danker Henrik Dommisch Rainer Haag |
| author_facet | Keerthana Rajes Peer Nölte Cynthia V. Yapto Kerstin Danker Henrik Dommisch Rainer Haag |
| author_sort | Keerthana Rajes |
| collection | DOAJ |
| description | A synthetic route for adhesive core-multishell (CMS) nanocarriers for application to the oral mucosa was established using mussel-inspired catechol moieties. The three CMS nanocarriers with 8%, 13%, and 20% catechol functionalization were evaluated for loading capacity using Nile red, showing an overall loading of 1 wt%. The ability of Nile red loaded and functionalized nanocarriers to bind to a moist mucosal surface was tested in two complementary adhesion assays under static and dynamic conditions using monolayers of differentiated gingival keratinocytes. Adhesion properties of functionalized nanocarriers were compared to the adhesion of the non-functionalized nanocarrier. In both assays, the CMS nanocarrier functionalized with 8% catechol exhibited the strongest adhesion compared to its catechol-free counterpart and the CMS nanocarriers functionalized with 13% and 20% catechol. |
| first_indexed | 2024-03-10T03:08:27Z |
| format | Article |
| id | doaj.art-52c6f90261f94240b9d44b50c9def5a6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:08:27Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-52c6f90261f94240b9d44b50c9def5a62023-11-23T12:36:53ZengMDPI AGPharmaceutics1999-49232022-04-0114594010.3390/pharmaceutics14050940Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal TissuesKeerthana Rajes0Peer Nölte1Cynthia V. Yapto2Kerstin Danker3Henrik Dommisch4Rainer Haag5Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, GermanyInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, GermanyInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, GermanyInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, GermanyDepartment of Periodontology, Oral Medicine and Oral Surgery, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 14197 Berlin, GermanyInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, GermanyA synthetic route for adhesive core-multishell (CMS) nanocarriers for application to the oral mucosa was established using mussel-inspired catechol moieties. The three CMS nanocarriers with 8%, 13%, and 20% catechol functionalization were evaluated for loading capacity using Nile red, showing an overall loading of 1 wt%. The ability of Nile red loaded and functionalized nanocarriers to bind to a moist mucosal surface was tested in two complementary adhesion assays under static and dynamic conditions using monolayers of differentiated gingival keratinocytes. Adhesion properties of functionalized nanocarriers were compared to the adhesion of the non-functionalized nanocarrier. In both assays, the CMS nanocarrier functionalized with 8% catechol exhibited the strongest adhesion compared to its catechol-free counterpart and the CMS nanocarriers functionalized with 13% and 20% catechol.https://www.mdpi.com/1999-4923/14/5/940CMS nanocarriersadhesioncatecholoral mucosadrug delivery |
| spellingShingle | Keerthana Rajes Peer Nölte Cynthia V. Yapto Kerstin Danker Henrik Dommisch Rainer Haag Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues Pharmaceutics CMS nanocarriers adhesion catechol oral mucosa drug delivery |
| title | Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues |
| title_full | Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues |
| title_fullStr | Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues |
| title_full_unstemmed | Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues |
| title_short | Novel Adhesive Nanocarriers Based on Mussel-Inspired Polyglycerols for the Application onto Mucosal Tissues |
| title_sort | novel adhesive nanocarriers based on mussel inspired polyglycerols for the application onto mucosal tissues |
| topic | CMS nanocarriers adhesion catechol oral mucosa drug delivery |
| url | https://www.mdpi.com/1999-4923/14/5/940 |
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