Choline: An Essential Nutrient for Skeletal Muscle
Background: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/2144 |
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| author | Antimo Moretti Marco Paoletta Sara Liguori Matteo Bertone Giuseppe Toro Giovanni Iolascon |
| author_facet | Antimo Moretti Marco Paoletta Sara Liguori Matteo Bertone Giuseppe Toro Giovanni Iolascon |
| author_sort | Antimo Moretti |
| collection | DOAJ |
| description | Background: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications. Methods: A technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “choline” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms ”skeletal muscle” and “muscle striated”. TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language. Results: From the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies. Conclusions: Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy. |
| first_indexed | 2024-03-10T18:22:40Z |
| format | Article |
| id | doaj.art-52c8a2d61a324cdbbee4a75b3378b273 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:22:40Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-52c8a2d61a324cdbbee4a75b3378b2732023-11-20T07:13:30ZengMDPI AGNutrients2072-66432020-07-01127214410.3390/nu12072144Choline: An Essential Nutrient for Skeletal MuscleAntimo Moretti0Marco Paoletta1Sara Liguori2Matteo Bertone3Giuseppe Toro4Giovanni Iolascon5Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyBackground: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications. Methods: A technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “choline” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms ”skeletal muscle” and “muscle striated”. TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language. Results: From the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies. Conclusions: Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.https://www.mdpi.com/2072-6643/12/7/2144cholineskeletal musclestriated musclereviewmuscle fatmuscle protein |
| spellingShingle | Antimo Moretti Marco Paoletta Sara Liguori Matteo Bertone Giuseppe Toro Giovanni Iolascon Choline: An Essential Nutrient for Skeletal Muscle Nutrients choline skeletal muscle striated muscle review muscle fat muscle protein |
| title | Choline: An Essential Nutrient for Skeletal Muscle |
| title_full | Choline: An Essential Nutrient for Skeletal Muscle |
| title_fullStr | Choline: An Essential Nutrient for Skeletal Muscle |
| title_full_unstemmed | Choline: An Essential Nutrient for Skeletal Muscle |
| title_short | Choline: An Essential Nutrient for Skeletal Muscle |
| title_sort | choline an essential nutrient for skeletal muscle |
| topic | choline skeletal muscle striated muscle review muscle fat muscle protein |
| url | https://www.mdpi.com/2072-6643/12/7/2144 |
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