Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption

Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption

Though both genetic and lifestyle factors are known to influence cardiometabolic outcomes, less attention has been given to whether lifestyle exposures can alter the association between a genetic variant and these outcomes. The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Co...

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Bibliographic Details
Main Authors: Timothy D. Majarian, Amy R. Bentley, Vincent Laville, Michael R. Brown, Daniel I. Chasman, Paul S. de Vries, Mary F. Feitosa, Nora Franceschini, W. James Gauderman, Casey Marchek, Daniel Levy, Alanna C. Morrison, Michael Province, Dabeeru C. Rao, Karen Schwander, Yun Ju Sung, Charles N. Rotimi, Hugues Aschard, C. Charles Gu, Alisa K. Manning, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genetics
Subjects:
multi-omics
gene-lifestyle interactions
smoking
alcohol
serum lipids
blood pressure
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.954713/full

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