Pregnancy in lupus: an updated consensus to guide best practice strategies
Abstract Background Systemic lupus erythematosus is a multifaceted chronic relapsing autoimmune disease of unknown etiology. The disease has always been a serious diagnosis in women being a multisystem pathology that is classically encountered during the childbearing age posing serious systemic como...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-12-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-022-00167-5 |
| _version_ | 1828083332525588480 |
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| author | Reem Hamdy A. Mohammed Hassan Mumtaz Abdul Basit Sangah Shazia Saleem Shaikh Noreen Nasir Sidra Jabeen |
| author_facet | Reem Hamdy A. Mohammed Hassan Mumtaz Abdul Basit Sangah Shazia Saleem Shaikh Noreen Nasir Sidra Jabeen |
| author_sort | Reem Hamdy A. Mohammed |
| collection | DOAJ |
| description | Abstract Background Systemic lupus erythematosus is a multifaceted chronic relapsing autoimmune disease of unknown etiology. The disease has always been a serious diagnosis in women being a multisystem pathology that is classically encountered during the childbearing age posing serious systemic comorbidities with a potential impact on the functional performance, psychosocial status, and survival. In this article, we review critical issues related to the decision to conceive in female with lupus highlighting the impact of the diagnosis and disease activity status on the mother and the fetus, attempting to suggest a consensus to guide safe decision making for pregnancy with SLE. Main body The pleomorphic dysregulated immune nature of lupus in the presence of uncontrolled disease carries a higher risk of complicated pregnancy. Therefore, SLE pregnancies should be well planned and are usually encouraged if the disease is inactive (at least 6 months prior to conception) to ensure immune quiescence towards a safer outcome. Conclusion With the proper implementation of preconception counseling strategy, choice of the correct timing of conception, close monitoring of SLE flares with tight control, and the appreciation of the value of multidisciplinary management to best practice most young women with SLE can carry on successful pregnancies with favorable outcome. |
| first_indexed | 2024-04-11T04:06:11Z |
| format | Article |
| id | doaj.art-52cf14a34db248f087625198d9adfe39 |
| institution | Directory Open Access Journal |
| issn | 1110-161X 2090-3235 |
| language | English |
| last_indexed | 2024-04-11T04:06:11Z |
| publishDate | 2022-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-52cf14a34db248f087625198d9adfe392023-01-01T12:21:06ZengSpringerOpenEgyptian Rheumatology and Rehabilitation1110-161X2090-32352022-12-0149111110.1186/s43166-022-00167-5Pregnancy in lupus: an updated consensus to guide best practice strategiesReem Hamdy A. Mohammed0Hassan Mumtaz1Abdul Basit Sangah2Shazia Saleem Shaikh3Noreen Nasir4Sidra Jabeen5Department of Rheumatology and Rehabilitation, School of Medicine, Cairo UniversityHealth Services Academy, Maroof international Hospital Public Health ScholarLiaquat National Hospital and Medical CollegeLiaquat National Hospital and Medical CollegeInternal Medicine, Aga Khan University HospitalLiaquat National Hospital and Medical CollegeAbstract Background Systemic lupus erythematosus is a multifaceted chronic relapsing autoimmune disease of unknown etiology. The disease has always been a serious diagnosis in women being a multisystem pathology that is classically encountered during the childbearing age posing serious systemic comorbidities with a potential impact on the functional performance, psychosocial status, and survival. In this article, we review critical issues related to the decision to conceive in female with lupus highlighting the impact of the diagnosis and disease activity status on the mother and the fetus, attempting to suggest a consensus to guide safe decision making for pregnancy with SLE. Main body The pleomorphic dysregulated immune nature of lupus in the presence of uncontrolled disease carries a higher risk of complicated pregnancy. Therefore, SLE pregnancies should be well planned and are usually encouraged if the disease is inactive (at least 6 months prior to conception) to ensure immune quiescence towards a safer outcome. Conclusion With the proper implementation of preconception counseling strategy, choice of the correct timing of conception, close monitoring of SLE flares with tight control, and the appreciation of the value of multidisciplinary management to best practice most young women with SLE can carry on successful pregnancies with favorable outcome.https://doi.org/10.1186/s43166-022-00167-5Systemic lupus erythematosusImmune response in pregnancyPregnancy outcomesRiskBenefitIn vitro fertilization |
| spellingShingle | Reem Hamdy A. Mohammed Hassan Mumtaz Abdul Basit Sangah Shazia Saleem Shaikh Noreen Nasir Sidra Jabeen Pregnancy in lupus: an updated consensus to guide best practice strategies Egyptian Rheumatology and Rehabilitation Systemic lupus erythematosus Immune response in pregnancy Pregnancy outcomes Risk Benefit In vitro fertilization |
| title | Pregnancy in lupus: an updated consensus to guide best practice strategies |
| title_full | Pregnancy in lupus: an updated consensus to guide best practice strategies |
| title_fullStr | Pregnancy in lupus: an updated consensus to guide best practice strategies |
| title_full_unstemmed | Pregnancy in lupus: an updated consensus to guide best practice strategies |
| title_short | Pregnancy in lupus: an updated consensus to guide best practice strategies |
| title_sort | pregnancy in lupus an updated consensus to guide best practice strategies |
| topic | Systemic lupus erythematosus Immune response in pregnancy Pregnancy outcomes Risk Benefit In vitro fertilization |
| url | https://doi.org/10.1186/s43166-022-00167-5 |
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