Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification
Background: Aortic valve calcification correlates with the severity of aortic valve stenosis and a high calcium score is associated with conduction disturbances and paravalvular leakage after transcatheter aortic valve replacement. The 3mensio Structural Heart is a semiautomated software package to...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Structural Heart |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2474870622019212 |
| _version_ | 1827989256630435840 |
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| author | Thijmen W. Hokken, MD Joris F. Ooms, MD Isabella Kardys, MD, PhD Alexander Hirsch, MD, PhD Annick C. Weustink, MD, PhD Sanne Schipper, MSc Peter Heil, MSc Joost Daemen, MD, PhD Ricardo P.J. Budde, MD, PhD Nicolas M. Van Mieghem, MD, PhD |
| author_facet | Thijmen W. Hokken, MD Joris F. Ooms, MD Isabella Kardys, MD, PhD Alexander Hirsch, MD, PhD Annick C. Weustink, MD, PhD Sanne Schipper, MSc Peter Heil, MSc Joost Daemen, MD, PhD Ricardo P.J. Budde, MD, PhD Nicolas M. Van Mieghem, MD, PhD |
| author_sort | Thijmen W. Hokken, MD |
| collection | DOAJ |
| description | Background: Aortic valve calcification correlates with the severity of aortic valve stenosis and a high calcium score is associated with conduction disturbances and paravalvular leakage after transcatheter aortic valve replacement. The 3mensio Structural Heart is a semiautomated software package to facilitate aortic root analysis by multislice computed tomography.The aim of the contemporary study is to validate a semiautomated calcium quantification scoring tool with a conventional manual calcium quantification tool. Methods: Fifty randomly selected patients who underwent multislice computed tomography for preprocedural planning were retrospectively selected to compare the semiautomated aortic valve Agatston calcium score by 3mensio with the manually obtained score using IntelliSpace Portal as standard reference. Results: Patients had a mean age of 76.7 ± 7.4 years and 60% were male. The median Agatston score was 3390 [interquartile range 1877-4509] with 3mensio and 3434 [interquartile range 1839-4620] with IntelliSpace.The mean difference was -0.18 [95% confidence interval (CI) −53.8 to 53.4]. The intraclass correlation coefficient between the Agatston scores using IntelliSpace and 3mensio showed an excellent correlation of 0.995 [95% CI 0.992-0.997], p ≤ 0.001. The interobserver and intraobserver variability was 0.993 ([95% CI 0.961-0.998], p ≤ 0.001) and 0.995([95%CI 0.981-0.999], p = <0.001), respectively. Conclusions: The semiautomated calcium quantification module in 3mensio Structural Heart highly correlated with a conventional manual calcium scoring tool. |
| first_indexed | 2024-04-10T00:16:27Z |
| format | Article |
| id | doaj.art-52d2030f3c9a43a7ab995396d0fb77a4 |
| institution | Directory Open Access Journal |
| issn | 2474-8706 |
| language | English |
| last_indexed | 2024-04-10T00:16:27Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Structural Heart |
| spelling | doaj.art-52d2030f3c9a43a7ab995396d0fb77a42023-03-16T05:05:55ZengElsevierStructural Heart2474-87062023-03-0172100122Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium QuantificationThijmen W. Hokken, MD0Joris F. Ooms, MD1Isabella Kardys, MD, PhD2Alexander Hirsch, MD, PhD3Annick C. Weustink, MD, PhD4Sanne Schipper, MSc5Peter Heil, MSc6Joost Daemen, MD, PhD7Ricardo P.J. Budde, MD, PhD8Nicolas M. Van Mieghem, MD, PhD9Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsPie Medical Imaging, Maastricht, the Netherlands3mensio Medical Imaging, Bilthoven, the NetherlandsDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands; Address correspondence to: Nicolas M. Van Mieghem, MD, PhD, Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, Office Nt 645, Dr Molewaterplein 40 3015 GD, Rotterdam, the Netherlands.Background: Aortic valve calcification correlates with the severity of aortic valve stenosis and a high calcium score is associated with conduction disturbances and paravalvular leakage after transcatheter aortic valve replacement. The 3mensio Structural Heart is a semiautomated software package to facilitate aortic root analysis by multislice computed tomography.The aim of the contemporary study is to validate a semiautomated calcium quantification scoring tool with a conventional manual calcium quantification tool. Methods: Fifty randomly selected patients who underwent multislice computed tomography for preprocedural planning were retrospectively selected to compare the semiautomated aortic valve Agatston calcium score by 3mensio with the manually obtained score using IntelliSpace Portal as standard reference. Results: Patients had a mean age of 76.7 ± 7.4 years and 60% were male. The median Agatston score was 3390 [interquartile range 1877-4509] with 3mensio and 3434 [interquartile range 1839-4620] with IntelliSpace.The mean difference was -0.18 [95% confidence interval (CI) −53.8 to 53.4]. The intraclass correlation coefficient between the Agatston scores using IntelliSpace and 3mensio showed an excellent correlation of 0.995 [95% CI 0.992-0.997], p ≤ 0.001. The interobserver and intraobserver variability was 0.993 ([95% CI 0.961-0.998], p ≤ 0.001) and 0.995([95%CI 0.981-0.999], p = <0.001), respectively. Conclusions: The semiautomated calcium quantification module in 3mensio Structural Heart highly correlated with a conventional manual calcium scoring tool.http://www.sciencedirect.com/science/article/pii/S2474870622019212Agatston scoreAortic valve calcificationAortic valve stenosis |
| spellingShingle | Thijmen W. Hokken, MD Joris F. Ooms, MD Isabella Kardys, MD, PhD Alexander Hirsch, MD, PhD Annick C. Weustink, MD, PhD Sanne Schipper, MSc Peter Heil, MSc Joost Daemen, MD, PhD Ricardo P.J. Budde, MD, PhD Nicolas M. Van Mieghem, MD, PhD Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification Structural Heart Agatston score Aortic valve calcification Aortic valve stenosis |
| title | Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification |
| title_full | Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification |
| title_fullStr | Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification |
| title_full_unstemmed | Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification |
| title_short | Validation of a Three-Dimensional Computed Tomography Reconstruction Tool for Aortic Valve Calcium Quantification |
| title_sort | validation of a three dimensional computed tomography reconstruction tool for aortic valve calcium quantification |
| topic | Agatston score Aortic valve calcification Aortic valve stenosis |
| url | http://www.sciencedirect.com/science/article/pii/S2474870622019212 |
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