Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
Abstract In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13016-4 |
| _version_ | 1811257320076738560 |
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| author | Manisha Chatterjee Prathul Nath Sachin Kadian Anshu Kumar Vishal Kumar Partha Roy Gaurav Manik Soumitra Satapathi |
| author_facet | Manisha Chatterjee Prathul Nath Sachin Kadian Anshu Kumar Vishal Kumar Partha Roy Gaurav Manik Soumitra Satapathi |
| author_sort | Manisha Chatterjee |
| collection | DOAJ |
| description | Abstract In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs were effectively quenched over a wide concentration range of DA (0–340 μM) with an ultra-low detection limit of 3.6 μM. The quenching mechanism involved photoinduced electron transfer process from BS-GQDs to dopamine-quinone, produced by the oxidization of DA under alkaline conditions. The proposed sensing mechanism was probed using a detailed study of UV–Vis absorbance, steady state and time resolved fluorescence spectroscopy. The high selectivity of the fluorescent sensor towards DA is established. Our study opens up the possibility of designing a low-cost biosensor which will be suitable for detecting DA in real samples. |
| first_indexed | 2024-04-12T17:55:31Z |
| format | Article |
| id | doaj.art-52d208cfc4aa4d2db97e8e3100d415a2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T17:55:31Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-52d208cfc4aa4d2db97e8e3100d415a22022-12-22T03:22:22ZengNature PortfolioScientific Reports2045-23222022-05-0112111010.1038/s41598-022-13016-4Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dotsManisha Chatterjee0Prathul Nath1Sachin Kadian2Anshu Kumar3Vishal Kumar4Partha Roy5Gaurav Manik6Soumitra Satapathi7Department of Biotechnology, Indian Institute of Technology RoorkeeDepartment of Physics, Indian Institute of Technology RoorkeeDepartment of Polymer and Process Engineering, Indian Institute of Technology RoorkeeDepartment of Physics, Indian Institute of Technology RoorkeeDepartment of Physics, Indian Institute of Technology RoorkeeDepartment of Biotechnology, Indian Institute of Technology RoorkeeDepartment of Polymer and Process Engineering, Indian Institute of Technology RoorkeeDepartment of Physics, Indian Institute of Technology RoorkeeAbstract In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs were effectively quenched over a wide concentration range of DA (0–340 μM) with an ultra-low detection limit of 3.6 μM. The quenching mechanism involved photoinduced electron transfer process from BS-GQDs to dopamine-quinone, produced by the oxidization of DA under alkaline conditions. The proposed sensing mechanism was probed using a detailed study of UV–Vis absorbance, steady state and time resolved fluorescence spectroscopy. The high selectivity of the fluorescent sensor towards DA is established. Our study opens up the possibility of designing a low-cost biosensor which will be suitable for detecting DA in real samples.https://doi.org/10.1038/s41598-022-13016-4 |
| spellingShingle | Manisha Chatterjee Prathul Nath Sachin Kadian Anshu Kumar Vishal Kumar Partha Roy Gaurav Manik Soumitra Satapathi Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots Scientific Reports |
| title | Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots |
| title_full | Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots |
| title_fullStr | Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots |
| title_full_unstemmed | Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots |
| title_short | Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots |
| title_sort | highly sensitive and selective detection of dopamine with boron and sulfur co doped graphene quantum dots |
| url | https://doi.org/10.1038/s41598-022-13016-4 |
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