Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data g...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/21/11584 |
| _version_ | 1797512421604065280 |
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| author | Annia Galano Eduardo G. Guzmán-López Russel J. Reiter |
| author_facet | Annia Galano Eduardo G. Guzmán-López Russel J. Reiter |
| author_sort | Annia Galano |
| collection | DOAJ |
| description | Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives. |
| first_indexed | 2024-03-10T06:01:35Z |
| format | Article |
| id | doaj.art-52d21d493cb84eeb946ad9b6751b5f69 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:35Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-52d21d493cb84eeb946ad9b6751b5f692023-11-22T20:54:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211158410.3390/ijms222111584Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative DisordersAnnia Galano0Eduardo G. Guzmán-López1Russel J. Reiter2Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa C.P., Mexico City 09340, MexicoDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa C.P., Mexico City 09340, MexicoDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USAAlthough melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.https://www.mdpi.com/1422-0067/22/21/11584multifactorial diseasesmultifunctional drugsantioxidantneuroprotectionfree radical scavengersmetal chelators |
| spellingShingle | Annia Galano Eduardo G. Guzmán-López Russel J. Reiter Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders International Journal of Molecular Sciences multifactorial diseases multifunctional drugs antioxidant neuroprotection free radical scavengers metal chelators |
| title | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| title_full | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| title_fullStr | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| title_full_unstemmed | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| title_short | Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders |
| title_sort | potentiating the benefits of melatonin through chemical functionalization possible impact on multifactorial neurodegenerative disorders |
| topic | multifactorial diseases multifunctional drugs antioxidant neuroprotection free radical scavengers metal chelators |
| url | https://www.mdpi.com/1422-0067/22/21/11584 |
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