The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study
Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/9/1364 |
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| author | Adéla Holubová Lucie Chlupáčová Jitka Krocová Lada Cetlová Linsey J. F. Peters Niels A. J. Cremers Andrea Pokorná |
| author_facet | Adéla Holubová Lucie Chlupáčová Jitka Krocová Lada Cetlová Linsey J. F. Peters Niels A. J. Cremers Andrea Pokorná |
| author_sort | Adéla Holubová |
| collection | DOAJ |
| description | Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory features. This study aims to evaluate the effect of MGH therapy on infected non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (<i>n</i> = 5) of patients with wounds of diabetic foot syndrome are presented. There were five males with an average age of 61.6 years. All wounds were treated with MGH, and the healing trajectory was rigorously and objectively monitored. In all cases, there was a gradual disappearance of odour, pain, and exudation. Moreover, the wound areas significantly reduced within 40 days and there was a decrease in glycated haemoglobin and glycaemia values. All these outcomes resulted in improved quality of life of the patients. Despite bacterial colonisation, antibiotic treatment was not necessary. All wounds were completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in diabetic foot syndrome wounds, does not increase glycated haemoglobin or glycaemia levels, and thus constitutes an effective alternative to the use of antibiotics in the treatment of locally infected wounds. |
| first_indexed | 2024-03-10T23:06:22Z |
| format | Article |
| id | doaj.art-52d3350e89bd466598a4dc0ff1c2917a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T23:06:22Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-52d3350e89bd466598a4dc0ff1c2917a2023-11-19T09:16:45ZengMDPI AGAntibiotics2079-63822023-08-01129136410.3390/antibiotics12091364The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control StudyAdéla Holubová0Lucie Chlupáčová1Jitka Krocová2Lada Cetlová3Linsey J. F. Peters4Niels A. J. Cremers5Andrea Pokorná6Faculty of Health and Social Sciences, University of South Bohemia, 370 11 České Budějovice, Czech RepublicDiaPodi Care, spol. s r.o., 392 01 Soběslav, Czech RepublicDepartment of Nursing and Midwifery, Faculty of Health Studies, University of West Bohemia, 301 00 Pilsen, Czech RepublicDepartment of Health Sciences, College of Polytechnics Jihlava, 586 01 Jihlava, Czech RepublicTriticum Exploitatie BV, Sleperweg 44, 6222 NK Maastricht, The NetherlandsTriticum Exploitatie BV, Sleperweg 44, 6222 NK Maastricht, The NetherlandsDepartment of Health Sciences, College of Polytechnics Jihlava, 586 01 Jihlava, Czech RepublicNon-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory features. This study aims to evaluate the effect of MGH therapy on infected non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (<i>n</i> = 5) of patients with wounds of diabetic foot syndrome are presented. There were five males with an average age of 61.6 years. All wounds were treated with MGH, and the healing trajectory was rigorously and objectively monitored. In all cases, there was a gradual disappearance of odour, pain, and exudation. Moreover, the wound areas significantly reduced within 40 days and there was a decrease in glycated haemoglobin and glycaemia values. All these outcomes resulted in improved quality of life of the patients. Despite bacterial colonisation, antibiotic treatment was not necessary. All wounds were completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in diabetic foot syndrome wounds, does not increase glycated haemoglobin or glycaemia levels, and thus constitutes an effective alternative to the use of antibiotics in the treatment of locally infected wounds.https://www.mdpi.com/2079-6382/12/9/1364medical grade honeydiabetic foot ulcerdiabetesanti-inflammatory treatmentglycaemia |
| spellingShingle | Adéla Holubová Lucie Chlupáčová Jitka Krocová Lada Cetlová Linsey J. F. Peters Niels A. J. Cremers Andrea Pokorná The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study Antibiotics medical grade honey diabetic foot ulcer diabetes anti-inflammatory treatment glycaemia |
| title | The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study |
| title_full | The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study |
| title_fullStr | The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study |
| title_full_unstemmed | The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study |
| title_short | The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study |
| title_sort | use of medical grade honey on infected chronic diabetic foot ulcers a prospective case control study |
| topic | medical grade honey diabetic foot ulcer diabetes anti-inflammatory treatment glycaemia |
| url | https://www.mdpi.com/2079-6382/12/9/1364 |
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