A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences
Abstract Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlat...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20129-3 |
| _version_ | 1797998310711099392 |
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| author | Roxane Assaf Julien Ouellet Josiane Bourque Emmanuel Stip Marco Leyton Patricia Conrod Stéphane Potvin |
| author_facet | Roxane Assaf Julien Ouellet Josiane Bourque Emmanuel Stip Marco Leyton Patricia Conrod Stéphane Potvin |
| author_sort | Roxane Assaf |
| collection | DOAJ |
| description | Abstract Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlates of self-other processing in youth belonging to three developmental trajectories of psychotic experiences. Eighty-six youths were recruited from a longitudinal cohort of over 3800 adolescents based on their trajectories of Psychotic-Like Experiences from 12 to 16 years of age. Participants underwent neuroimaging at 17 years of age (mean). A functional neuroimaging task evaluating self- and other-related trait judgments was used to measure whole-brain activation and connectivity. Youth who showed an increasing trajectory displayed hypoactivation of the dorsomedial prefrontal cortex and hypoconnectivity with the cerebellum. By contrast, youth who showed a decreasing trajectory displayed decreased activation of the superior temporal gyrus, the inferior frontal gyrus, and the middle occipital gyrus. These findings suggest that the increasing trajectory is associated with alterations that might erode distinctions between self and other, influencing the emergence of symptoms such as hallucinations. The decreasing trajectory, in comparison, was associated with hypoactivations in areas influencing attention and basic information processing more generally. These alterations might affect the trajectories’ susceptibilities to positive vs. negative symptoms, respectively. |
| first_indexed | 2024-04-11T10:46:40Z |
| format | Article |
| id | doaj.art-52e0b80bdcf74e97aa72433d52dc767d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T10:46:40Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-52e0b80bdcf74e97aa72433d52dc767d2022-12-22T04:29:01ZengNature PortfolioScientific Reports2045-23222022-09-0112111110.1038/s41598-022-20129-3A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiencesRoxane Assaf0Julien Ouellet1Josiane Bourque2Emmanuel Stip3Marco Leyton4Patricia Conrod5Stéphane Potvin6Centre de Recherche, Institut Universitaire en Santé Mentale de MontréalDepartment of Psychiatry and Addiction, Faculty of Medicine, University of MontrealDepartment of Psychiatry, Perelman Faculty of Medicine, University of PennsylvaniaDepartment of Psychiatry and Addiction, Faculty of Medicine, University of MontrealDepartment of Psychiatry, Faculty of Medicine, McGill UniversityDepartment of Psychiatry and Addiction, Faculty of Medicine, University of MontrealCentre de Recherche, Institut Universitaire en Santé Mentale de MontréalAbstract Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlates of self-other processing in youth belonging to three developmental trajectories of psychotic experiences. Eighty-six youths were recruited from a longitudinal cohort of over 3800 adolescents based on their trajectories of Psychotic-Like Experiences from 12 to 16 years of age. Participants underwent neuroimaging at 17 years of age (mean). A functional neuroimaging task evaluating self- and other-related trait judgments was used to measure whole-brain activation and connectivity. Youth who showed an increasing trajectory displayed hypoactivation of the dorsomedial prefrontal cortex and hypoconnectivity with the cerebellum. By contrast, youth who showed a decreasing trajectory displayed decreased activation of the superior temporal gyrus, the inferior frontal gyrus, and the middle occipital gyrus. These findings suggest that the increasing trajectory is associated with alterations that might erode distinctions between self and other, influencing the emergence of symptoms such as hallucinations. The decreasing trajectory, in comparison, was associated with hypoactivations in areas influencing attention and basic information processing more generally. These alterations might affect the trajectories’ susceptibilities to positive vs. negative symptoms, respectively.https://doi.org/10.1038/s41598-022-20129-3 |
| spellingShingle | Roxane Assaf Julien Ouellet Josiane Bourque Emmanuel Stip Marco Leyton Patricia Conrod Stéphane Potvin A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences Scientific Reports |
| title | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
| title_full | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
| title_fullStr | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
| title_full_unstemmed | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
| title_short | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
| title_sort | functional neuroimaging study of self other processing alterations in atypical developmental trajectories of psychotic like experiences |
| url | https://doi.org/10.1038/s41598-022-20129-3 |
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