Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults?
It is a new and exciting time for acute lymphoblastic leukemia (ALL). While nearly 50 years ago, only one in nine children with ALL survived with chemotherapy, nowadays nearly 90% of children have a chance of long-term survival. Adults with ALL, as well as the special category of adolescents and you...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/15/3886 |
| _version_ | 1797525714849759232 |
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| author | Alexandra Neaga Laura Jimbu Oana Mesaros Madalina Bota Diana Lazar Simona Cainap Cristina Blag Mihnea Zdrenghea |
| author_facet | Alexandra Neaga Laura Jimbu Oana Mesaros Madalina Bota Diana Lazar Simona Cainap Cristina Blag Mihnea Zdrenghea |
| author_sort | Alexandra Neaga |
| collection | DOAJ |
| description | It is a new and exciting time for acute lymphoblastic leukemia (ALL). While nearly 50 years ago, only one in nine children with ALL survived with chemotherapy, nowadays nearly 90% of children have a chance of long-term survival. Adults with ALL, as well as the special category of adolescents and young adult (AYA) patients, are catching up with the new developments seen in children, but still their prognosis is much worse. A plethora of factors are regarded as responsible for the differences in treatment response, such as age, ethnicity, disease biology, treatment regimens and toxicities, drug tolerance and resistance, minimal residual disease evaluation, hematopoietic stem cell transplantation timing and socio-economic factors. Taking these factors into account, bringing pediatric-like protocols to adult patient management and incorporating new agents into frontline treatment could be the key to improve the survival rates in adults and AYA. |
| first_indexed | 2024-03-10T09:16:57Z |
| format | Article |
| id | doaj.art-52e0c45925014b099d217ef2fef29be0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:16:57Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-52e0c45925014b099d217ef2fef29be02023-11-22T05:29:29ZengMDPI AGCancers2072-66942021-08-011315388610.3390/cancers13153886Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults?Alexandra Neaga0Laura Jimbu1Oana Mesaros2Madalina Bota3Diana Lazar4Simona Cainap5Cristina Blag6Mihnea Zdrenghea7Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Mother and Child, Iuliu Haţieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, RomaniaDepartment of Pediatric Oncology and Hematology, Emergency Hospital for Children, 400177 Cluj-Napoca, RomaniaDepartment of Mother and Child, Iuliu Haţieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, RomaniaDepartment of Pediatric Oncology and Hematology, Emergency Hospital for Children, 400177 Cluj-Napoca, RomaniaDepartment of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaIt is a new and exciting time for acute lymphoblastic leukemia (ALL). While nearly 50 years ago, only one in nine children with ALL survived with chemotherapy, nowadays nearly 90% of children have a chance of long-term survival. Adults with ALL, as well as the special category of adolescents and young adult (AYA) patients, are catching up with the new developments seen in children, but still their prognosis is much worse. A plethora of factors are regarded as responsible for the differences in treatment response, such as age, ethnicity, disease biology, treatment regimens and toxicities, drug tolerance and resistance, minimal residual disease evaluation, hematopoietic stem cell transplantation timing and socio-economic factors. Taking these factors into account, bringing pediatric-like protocols to adult patient management and incorporating new agents into frontline treatment could be the key to improve the survival rates in adults and AYA.https://www.mdpi.com/2072-6694/13/15/3886acute lymphoblastic leukemiaprognosissurvival ratesadolescents and young adultsdifferences in treatment responsepediatric-like protocols |
| spellingShingle | Alexandra Neaga Laura Jimbu Oana Mesaros Madalina Bota Diana Lazar Simona Cainap Cristina Blag Mihnea Zdrenghea Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? Cancers acute lymphoblastic leukemia prognosis survival rates adolescents and young adults differences in treatment response pediatric-like protocols |
| title | Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? |
| title_full | Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? |
| title_fullStr | Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? |
| title_full_unstemmed | Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? |
| title_short | Why Do Children with Acute Lymphoblastic Leukemia Fare Better Than Adults? |
| title_sort | why do children with acute lymphoblastic leukemia fare better than adults |
| topic | acute lymphoblastic leukemia prognosis survival rates adolescents and young adults differences in treatment response pediatric-like protocols |
| url | https://www.mdpi.com/2072-6694/13/15/3886 |
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