Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness

Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness

Background: Mesenchymal stem cells (MSCs) have been used for ex vivo expansion of umbilical cord blood (UCB) hematopoietic stem cells (HSCs) to maintain their primitive characters and long-term reconstitution abilities during transplantation. Therapeutic effects of MSCs mainly rely on paracrine mech...

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Bibliographic Details
Main Authors: Rasha S. Teleb, Amal Abdul-Hafez, Amira Othman, Ahmed El-Abd Ahmed, Abdelrahman A. Elsaid, Hattan Arif, Ahmed A. Zarea, Mohammed Abdulmageed, Hend Mohamed, Sherif Abdelfattah Ibrahim, Ranga P. Thiruvenkataramani, Tarek Mohamed, Masamitsu Kanada, Burra V. Madhukar, Myrna Gonzalez Arellano, Mohammed M. Sayed, Heba M. Qubaisy, Said A. Omar
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
placenta
umbilical cord
umbilical cord blood transplantation
mesenchymal stem cells
hematopoietic stem cells
extracellular vesicles (EVs)
Online Access:https://www.mdpi.com/2073-4409/12/2/250

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