PI3K/AKT and STAT3 pathways mediate the neuroprotective effect of dasatinib from acute cerebral injury in endotoxemic mice

PI3K/AKT and STAT3 pathways mediate the neuroprotective effect of dasatinib from acute cerebral injury in endotoxemic mice

Background and purpose: Sepsis induces brain dysfunction and there is still a requirement for an unemployed viable restorative approach. This study aimed to investigate the role of dasatinib in the modulation of proinflammatory mediators, attenuating neuroinflammatory response, and it's signali...

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Bibliographic Details
Main Authors: Ammar Rasoul Mohammad, Ekhlas Sabah Hassan, Sahar Abdulrudha Majeed
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
clp; dasatinib; endotoxemia; sepsis.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2024;volume=19;issue=1;spage=64;epage=72;aulast=Mohammad

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