CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

Abstract Background The annual incidence of traumatic brain injury (TBI) in the United States is over 2.5 million, with approximately 3–5 million people living with chronic sequelae. Compared with moderate-severe TBI, the long-term effects of mild TBI (mTBI) are less understood but important to addr...

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Bibliographic Details
Main Authors: Wai Hang Cheng, Kris M. Martens, Asma Bashir, Honor Cheung, Sophie Stukas, Ebrima Gibbs, Dhananjay R. Namjoshi, Emily B. Button, Anna Wilkinson, Carlos J. Barron, Neil R. Cashman, Peter A. Cripton, Cheryl L. Wellington
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Traumatic brain injury
CHIMERA
Alzheimer disease mice
Post-traumatic stress disorder
Spatial memory
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13195-018-0461-0

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