Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail
Globally, millions of people suffer from various substance use disorders (SUD), including mono-and polydrug use of opioids and methamphetamine. Brain regions such as the cingulate cortex, infralimbic cortex, dorsal striatum, nucleus accumbens, basolateral and central amygdala have been shown to play...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.859563/full |
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| author | Hanis Mohammad Hazani Isa Naina Mohamed Mustapha Muzaimi Wael Mohamed Wael Mohamed Mohamad Fairuz Yahaya Seong Lin Teoh Rashidi Mohamed Pakri Mohamed Mohd Fadzli Mohamad Isa Sundus Mansoor Abdulrahman Ravi Ramadah Mohammad Rahim Kamaluddin Jaya Kumar |
| author_facet | Hanis Mohammad Hazani Isa Naina Mohamed Mustapha Muzaimi Wael Mohamed Wael Mohamed Mohamad Fairuz Yahaya Seong Lin Teoh Rashidi Mohamed Pakri Mohamed Mohd Fadzli Mohamad Isa Sundus Mansoor Abdulrahman Ravi Ramadah Mohammad Rahim Kamaluddin Jaya Kumar |
| author_sort | Hanis Mohammad Hazani |
| collection | DOAJ |
| description | Globally, millions of people suffer from various substance use disorders (SUD), including mono-and polydrug use of opioids and methamphetamine. Brain regions such as the cingulate cortex, infralimbic cortex, dorsal striatum, nucleus accumbens, basolateral and central amygdala have been shown to play important roles in addiction-related behavioral changes. Clinical and pre-clinical studies have characterized these brain regions and their corresponding neurochemical changes in numerous phases of drug dependence such as acute drug use, intoxication, craving, withdrawal, and relapse. At present, many studies have reported the individual effects of opioids and methamphetamine. However, little is known about their combined effects. Co-use of these drugs produces effects greater than either drug alone, where one decreases the side effects of the other, and the combination produces a prolonged intoxication period or a more desirable intoxication effect. An increasing number of studies have associated polydrug abuse with poorer treatment outcomes, drug-related deaths, and more severe psychopathologies. To date, the pharmacological treatment efficacy for polydrug abuse is vague, and still at the experimental stage. This present review discusses the human and animal behavioral, neuroanatomical, and neurochemical changes underlying both morphine and methamphetamine dependence separately, as well as its combination. This narrative review also delineates the recent advances in the pharmacotherapy of mono- and poly drug-use of opioids and methamphetamine at clinical and preclinical stages. |
| first_indexed | 2024-12-21T01:12:08Z |
| format | Article |
| id | doaj.art-52e3986e37d34ac49880191b6ac807ad |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T01:12:08Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-52e3986e37d34ac49880191b6ac807ad2022-12-21T19:20:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.859563859563Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly CocktailHanis Mohammad Hazani0Isa Naina Mohamed1Mustapha Muzaimi2Wael Mohamed3Wael Mohamed4Mohamad Fairuz Yahaya5Seong Lin Teoh6Rashidi Mohamed Pakri Mohamed7Mohd Fadzli Mohamad Isa8Sundus Mansoor Abdulrahman9Ravi Ramadah10Mohammad Rahim Kamaluddin11Jaya Kumar12Department of Physiology, Faculty of Medicine, The National University of Malaysia, Cheras, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Cheras, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBasic Medical Science Department, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, MalaysiaFaculty of Medicine, Department of Clinical Pharmacology, Menoufia University, Shebin El-Kom, EgyptDepartment of Anatomy, Faculty of Medicine, National University of Malaysia, Cheras, MalaysiaDepartment of Anatomy, Faculty of Medicine, National University of Malaysia, Cheras, MalaysiaDepartment of Family Medicine, Faculty of Medicine, The National University of Malaysia, Cheras, MalaysiaDepartment of Psychiatry and Mental Health, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaNewcastle University Medicine Malaysia, Johor, Malaysia0National Anti-Drugs Agency Malaysia, Selangor, Malaysia1Centre for Research in Psychology and Human Well-Being, Faculty of Social Sciences and Humanities, The National University of Malaysia, Bangi, MalaysiaDepartment of Physiology, Faculty of Medicine, The National University of Malaysia, Cheras, MalaysiaGlobally, millions of people suffer from various substance use disorders (SUD), including mono-and polydrug use of opioids and methamphetamine. Brain regions such as the cingulate cortex, infralimbic cortex, dorsal striatum, nucleus accumbens, basolateral and central amygdala have been shown to play important roles in addiction-related behavioral changes. Clinical and pre-clinical studies have characterized these brain regions and their corresponding neurochemical changes in numerous phases of drug dependence such as acute drug use, intoxication, craving, withdrawal, and relapse. At present, many studies have reported the individual effects of opioids and methamphetamine. However, little is known about their combined effects. Co-use of these drugs produces effects greater than either drug alone, where one decreases the side effects of the other, and the combination produces a prolonged intoxication period or a more desirable intoxication effect. An increasing number of studies have associated polydrug abuse with poorer treatment outcomes, drug-related deaths, and more severe psychopathologies. To date, the pharmacological treatment efficacy for polydrug abuse is vague, and still at the experimental stage. This present review discusses the human and animal behavioral, neuroanatomical, and neurochemical changes underlying both morphine and methamphetamine dependence separately, as well as its combination. This narrative review also delineates the recent advances in the pharmacotherapy of mono- and poly drug-use of opioids and methamphetamine at clinical and preclinical stages.https://www.frontiersin.org/articles/10.3389/fphar.2022.859563/fulladdictiondependencepolydrugpolysubstanceopioidmethamphetamine |
| spellingShingle | Hanis Mohammad Hazani Isa Naina Mohamed Mustapha Muzaimi Wael Mohamed Wael Mohamed Mohamad Fairuz Yahaya Seong Lin Teoh Rashidi Mohamed Pakri Mohamed Mohd Fadzli Mohamad Isa Sundus Mansoor Abdulrahman Ravi Ramadah Mohammad Rahim Kamaluddin Jaya Kumar Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail Frontiers in Pharmacology addiction dependence polydrug polysubstance opioid methamphetamine |
| title | Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail |
| title_full | Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail |
| title_fullStr | Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail |
| title_full_unstemmed | Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail |
| title_short | Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail |
| title_sort | goofballing of opioid and methamphetamine the science behind the deadly cocktail |
| topic | addiction dependence polydrug polysubstance opioid methamphetamine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.859563/full |
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