Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study
Background: Osteoporosis increases the fracture and mortality risk of patients and has a higher disease burden than some cancers. Therefore, global concerns regarding the prevention and treatment of osteoporosis have been raised. However, fast-aging Taiwan lacks national epidemiological data on oste...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664623001523 |
| _version_ | 1797665403103608832 |
|---|---|
| author | Ming-Tsung Lee Shau-Huai Fu Chih-Cheng Hsu Ho-Min Chen Jou-Wei Lin Keh-Sung Tsai Jawl-Shan Hwang Sheng-Chieh Lin Chih-Hsing Wu Chen-Yu Wang |
| author_facet | Ming-Tsung Lee Shau-Huai Fu Chih-Cheng Hsu Ho-Min Chen Jou-Wei Lin Keh-Sung Tsai Jawl-Shan Hwang Sheng-Chieh Lin Chih-Hsing Wu Chen-Yu Wang |
| author_sort | Ming-Tsung Lee |
| collection | DOAJ |
| description | Background: Osteoporosis increases the fracture and mortality risk of patients and has a higher disease burden than some cancers. Therefore, global concerns regarding the prevention and treatment of osteoporosis have been raised. However, fast-aging Taiwan lacks national epidemiological data on osteoporosis in recent years. We aimed to establish and update epidemiological data on osteoporosis by analyzing national data from 2008 to 2019. Methods: We estimated the prevalence and incidence of osteoporosis in patients aged ≥50 years based on claims data from Taiwan's National Health Insurance database from 2008 to 2019. We also analyzed the key parameters of fracture care (anti-osteoporosis medication use, bone mineral density examination rate, and length of hospital stay) to understand the secular trend of management and related clinical outcomes (imminent refracture rate and mortality). Results: The number of prevalent osteoporosis increased from 2008 to 2015 and remained constant until 2019; however, the age-standardized prevalence and incidence rates declined from 2008 to 2019 (3.77%–2.91% and 2.08%–1.02%, respectively). The overall incidence rates of hip and spine fractures decreased significantly by 34% and 27%, respectively. For patients with hip and spine fractures, the immanent refracture rates were 8.5% and 12.9% and the 1-year mortality rate remained stable at approximately 15% and 6%, respectively. Conclusion: The age-standardized prevalence and incidence rates decreased remarkably from 2008 to 2019, while the number of prevalent osteoporosis remained steady. Patients with hip fractures encountered a high 1-year mortality rate, while the risk of imminent refracture was notable for patients with spine fractures. |
| first_indexed | 2024-03-11T19:43:20Z |
| format | Article |
| id | doaj.art-52e3aa0afae7429f8cb6629290039c7f |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-11T19:43:20Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-52e3aa0afae7429f8cb6629290039c7f2023-10-06T04:43:52ZengElsevierJournal of the Formosan Medical Association0929-66462023-01-01122S21S35Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based studyMing-Tsung Lee0Shau-Huai Fu1Chih-Cheng Hsu2Ho-Min Chen3Jou-Wei Lin4Keh-Sung Tsai5Jawl-Shan Hwang6Sheng-Chieh Lin7Chih-Hsing Wu8Chen-Yu Wang9National Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan; Department of Nursing, Hungkuang University, Taichung, TaiwanDepartment of Orthopedics, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Orthopedics, National Taiwan University Hospital, Taipei, TaiwanNational Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, TaiwanHealth Data Research Center, National Taiwan University, Taipei, TaiwanDepartment of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu, Yunlin County, TaiwanDepartment of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Linkou, TaiwanDepartment of Orthopaedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, TaiwanInstitute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Corresponding author. Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, No.1, University Road, Tainan City, 701, Taiwan.National Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan; Department of Pharmacy, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan; Corresponding author. National Center for Geriatrics and Welfare Research, National Health Research Institutes, No. 8 Xuefu W. Rd., Huwei Township, Yunlin County, 632, Taiwan.Background: Osteoporosis increases the fracture and mortality risk of patients and has a higher disease burden than some cancers. Therefore, global concerns regarding the prevention and treatment of osteoporosis have been raised. However, fast-aging Taiwan lacks national epidemiological data on osteoporosis in recent years. We aimed to establish and update epidemiological data on osteoporosis by analyzing national data from 2008 to 2019. Methods: We estimated the prevalence and incidence of osteoporosis in patients aged ≥50 years based on claims data from Taiwan's National Health Insurance database from 2008 to 2019. We also analyzed the key parameters of fracture care (anti-osteoporosis medication use, bone mineral density examination rate, and length of hospital stay) to understand the secular trend of management and related clinical outcomes (imminent refracture rate and mortality). Results: The number of prevalent osteoporosis increased from 2008 to 2015 and remained constant until 2019; however, the age-standardized prevalence and incidence rates declined from 2008 to 2019 (3.77%–2.91% and 2.08%–1.02%, respectively). The overall incidence rates of hip and spine fractures decreased significantly by 34% and 27%, respectively. For patients with hip and spine fractures, the immanent refracture rates were 8.5% and 12.9% and the 1-year mortality rate remained stable at approximately 15% and 6%, respectively. Conclusion: The age-standardized prevalence and incidence rates decreased remarkably from 2008 to 2019, while the number of prevalent osteoporosis remained steady. Patients with hip fractures encountered a high 1-year mortality rate, while the risk of imminent refracture was notable for patients with spine fractures.http://www.sciencedirect.com/science/article/pii/S0929664623001523AgingEpidemiologyFractureOsteoporosisPopulation-based study |
| spellingShingle | Ming-Tsung Lee Shau-Huai Fu Chih-Cheng Hsu Ho-Min Chen Jou-Wei Lin Keh-Sung Tsai Jawl-Shan Hwang Sheng-Chieh Lin Chih-Hsing Wu Chen-Yu Wang Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study Journal of the Formosan Medical Association Aging Epidemiology Fracture Osteoporosis Population-based study |
| title | Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study |
| title_full | Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study |
| title_fullStr | Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study |
| title_full_unstemmed | Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study |
| title_short | Epidemiology and clinical impact of osteoporosis in Taiwan: A 12-year trend of a nationwide population-based study |
| title_sort | epidemiology and clinical impact of osteoporosis in taiwan a 12 year trend of a nationwide population based study |
| topic | Aging Epidemiology Fracture Osteoporosis Population-based study |
| url | http://www.sciencedirect.com/science/article/pii/S0929664623001523 |
| work_keys_str_mv | AT mingtsunglee epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT shauhuaifu epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT chihchenghsu epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT hominchen epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT jouweilin epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT kehsungtsai epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT jawlshanhwang epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT shengchiehlin epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT chihhsingwu epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy AT chenyuwang epidemiologyandclinicalimpactofosteoporosisintaiwana12yeartrendofanationwidepopulationbasedstudy |