<i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity
Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated wit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/8/1618 |
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| author | Giuseppina Rosaria Umano Grazia Cirillo Giulia Rondinelli Gianmaria Sanchez Pierluigi Marzuillo Stefano Guarino Anna Di Sessa Alfonso Papparella Emanuele Miraglia del Giudice |
| author_facet | Giuseppina Rosaria Umano Grazia Cirillo Giulia Rondinelli Gianmaria Sanchez Pierluigi Marzuillo Stefano Guarino Anna Di Sessa Alfonso Papparella Emanuele Miraglia del Giudice |
| author_sort | Giuseppina Rosaria Umano |
| collection | DOAJ |
| description | Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated with an increased risk of hypertension in adolescents. In this study, we aimed to investigate the effect of <i>LSS</i> rs2254524 polymorphism on blood pressure in children and adolescents with obesity. We enrolled 828 obese children aged 6–17 years. Subjects carrying the A allele showed higher rates of systolic and diastolic stage I hypertension and stage II hypertension. Carriers of the A allele showed a 2.4-fold (95% C.I. 1.5–4.7, <i>p</i> = 0.01) higher risk for stage II hypertension and a 1.9-fold higher risk for stage I hypertension (95% C.I. 1.4–2.6, <i>p</i> < 0.0001). The risk was independent of confounding factors. In conclusion, <i>LSS</i> rs2254524 worsens the cardiovascular health of children and adolescents with obesity, increasing their blood pressure. |
| first_indexed | 2024-03-10T23:54:16Z |
| format | Article |
| id | doaj.art-52e70f542352420a911598f08d3bc853 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T23:54:16Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-52e70f542352420a911598f08d3bc8532023-11-19T01:16:01ZengMDPI AGGenes2073-44252023-08-01148161810.3390/genes14081618<i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with ObesityGiuseppina Rosaria Umano0Grazia Cirillo1Giulia Rondinelli2Gianmaria Sanchez3Pierluigi Marzuillo4Stefano Guarino5Anna Di Sessa6Alfonso Papparella7Emanuele Miraglia del Giudice8Department of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of the Woman, the Child, of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyChildhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated with an increased risk of hypertension in adolescents. In this study, we aimed to investigate the effect of <i>LSS</i> rs2254524 polymorphism on blood pressure in children and adolescents with obesity. We enrolled 828 obese children aged 6–17 years. Subjects carrying the A allele showed higher rates of systolic and diastolic stage I hypertension and stage II hypertension. Carriers of the A allele showed a 2.4-fold (95% C.I. 1.5–4.7, <i>p</i> = 0.01) higher risk for stage II hypertension and a 1.9-fold higher risk for stage I hypertension (95% C.I. 1.4–2.6, <i>p</i> < 0.0001). The risk was independent of confounding factors. In conclusion, <i>LSS</i> rs2254524 worsens the cardiovascular health of children and adolescents with obesity, increasing their blood pressure.https://www.mdpi.com/2073-4425/14/8/1618blood pressurechildren and adolescentsLSS rs2254524 |
| spellingShingle | Giuseppina Rosaria Umano Grazia Cirillo Giulia Rondinelli Gianmaria Sanchez Pierluigi Marzuillo Stefano Guarino Anna Di Sessa Alfonso Papparella Emanuele Miraglia del Giudice <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity Genes blood pressure children and adolescents LSS rs2254524 |
| title | <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity |
| title_full | <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity |
| title_fullStr | <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity |
| title_full_unstemmed | <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity |
| title_short | <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity |
| title_sort | i lss i rs2254524 increases the risk of hypertension in children and adolescents with obesity |
| topic | blood pressure children and adolescents LSS rs2254524 |
| url | https://www.mdpi.com/2073-4425/14/8/1618 |
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