Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”?
For over six decades intra-arterial (IA) drugs have been sporadically used for the treatment of lethal brain diseases. In recent years considerable advance has been made in the IA treatment of retinoblastomas, liver and locally invasive breast cancers, but relatively little progress has been made in...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-05-01
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| Series: | Journal of Neuroanaesthesiology and Critical Care |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2348-0548.130386 |
| _version_ | 1819074713179127808 |
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| author | Shailendra Joshi Jason A. Ellis Charles W. Emala |
| author_facet | Shailendra Joshi Jason A. Ellis Charles W. Emala |
| author_sort | Shailendra Joshi |
| collection | DOAJ |
| description | For over six decades intra-arterial (IA) drugs have been sporadically used for the treatment of lethal brain diseases. In recent years considerable advance has been made in the IA treatment of retinoblastomas, liver and locally invasive breast cancers, but relatively little progress has been made in the treatment of brain cancers. High resting blood flow and the presence of the blood-brain barrier (BBB), makes IA delivery to the brain tissue far more challenging, compared to other organs. The lack of advance in the field is also partly due to the inability to understand the complex pharmacokinetics of IA drugs as it is difficult to track drug concentrations in sub-second time frame by conventional chemical methods. The advances in optical imaging now provide unprecedented insights into the pharmacokinetics of IA drug and optical tracer delivery. Novel delivery methods, improved IA drug formulations, and optical pharmacokinetics, present us with untested paradigms in pharmacology that could lead to new therapeutic interventions for brain cancers and stroke. The object of this review is to bring into focus the current practice, problems, and the potential of IA drug delivery for treating brain diseases. A concerted effort is needed at basic sciences (pharmacology and drug imaging), and translational (drug delivery techniques and protocol development) levels by the interventional neuroradiology community to advance the field. |
| first_indexed | 2024-12-21T18:13:53Z |
| format | Article |
| id | doaj.art-52e72b5e5d054454a50f9753741887ac |
| institution | Directory Open Access Journal |
| issn | 2348-0548 2348-926X |
| language | English |
| last_indexed | 2024-12-21T18:13:53Z |
| publishDate | 2014-05-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Neuroanaesthesiology and Critical Care |
| spelling | doaj.art-52e72b5e5d054454a50f9753741887ac2022-12-21T18:54:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Neuroanaesthesiology and Critical Care2348-05482348-926X2014-05-01010210811510.4103/2348-0548.130386Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”?Shailendra Joshi0Jason A. Ellis1Charles W. Emala2Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NYDepartment of Neurosurgery, College of Physicians and Surgeons of Columbia University, New York, NYDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NYFor over six decades intra-arterial (IA) drugs have been sporadically used for the treatment of lethal brain diseases. In recent years considerable advance has been made in the IA treatment of retinoblastomas, liver and locally invasive breast cancers, but relatively little progress has been made in the treatment of brain cancers. High resting blood flow and the presence of the blood-brain barrier (BBB), makes IA delivery to the brain tissue far more challenging, compared to other organs. The lack of advance in the field is also partly due to the inability to understand the complex pharmacokinetics of IA drugs as it is difficult to track drug concentrations in sub-second time frame by conventional chemical methods. The advances in optical imaging now provide unprecedented insights into the pharmacokinetics of IA drug and optical tracer delivery. Novel delivery methods, improved IA drug formulations, and optical pharmacokinetics, present us with untested paradigms in pharmacology that could lead to new therapeutic interventions for brain cancers and stroke. The object of this review is to bring into focus the current practice, problems, and the potential of IA drug delivery for treating brain diseases. A concerted effort is needed at basic sciences (pharmacology and drug imaging), and translational (drug delivery techniques and protocol development) levels by the interventional neuroradiology community to advance the field.http://www.thieme-connect.de/DOI/DOI?10.4103/2348-0548.130386brain diseasesdrug deliveryintra-arterial |
| spellingShingle | Shailendra Joshi Jason A. Ellis Charles W. Emala Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? Journal of Neuroanaesthesiology and Critical Care brain diseases drug delivery intra-arterial |
| title | Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? |
| title_full | Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? |
| title_fullStr | Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? |
| title_full_unstemmed | Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? |
| title_short | Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”? |
| title_sort | revisiting intra arterial drug delivery for treating brain diseases or is it deja vu all over again |
| topic | brain diseases drug delivery intra-arterial |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/2348-0548.130386 |
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