Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC

The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by preventing the exposure of Env vulnerable epitopes. Small-molecule CD4 mimetics (CD4mc) based on the indane and piper...

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Bibliographic Details
Main Authors: Shilei Ding, William D. Tolbert, Huile Zhu, Daniel Lee, Lorie Marchitto, Tyler Higgins, Xuchen Zhao, Dung Nguyen, Rebekah Sherburn, Jonathan Richard, Gabrielle Gendron-Lepage, Halima Medjahed, Mohammadjavad Mohammadi, Cameron Abrams, Marzena Pazgier, Amos B. Smith, Andrés Finzi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
HIV-1
small CD4 mimetic compounds (CD4mc)
Phe43 cavity
envelope glycoproteins
neutralization
antibody-dependent cellular cytotoxicity (ADCC)
Online Access:https://www.mdpi.com/1999-4915/15/5/1185

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