TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis
Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfuration to maintain hepatic cysteine, coenzyme-A and g...
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Bibliographic Details
Main Authors: |
David Matye,
Sumedha Gunewardena,
Jianglei Chen,
Huaiwen Wang,
Yifeng Wang,
Mohammad Nazmul Hasan,
Lijie Gu,
Yung Dai Clayton,
Yanhong Du,
Cheng Chen,
Jacob E. Friedman,
Shelly C. Lu,
Wen-Xing Ding,
Tiangang Li |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2022-09-01
|
Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-022-33465-9
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