TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis
Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfuration to maintain hepatic cysteine, coenzyme-A and g...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33465-9 |
| _version_ | 1811236368887578624 |
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| author | David Matye Sumedha Gunewardena Jianglei Chen Huaiwen Wang Yifeng Wang Mohammad Nazmul Hasan Lijie Gu Yung Dai Clayton Yanhong Du Cheng Chen Jacob E. Friedman Shelly C. Lu Wen-Xing Ding Tiangang Li |
| author_facet | David Matye Sumedha Gunewardena Jianglei Chen Huaiwen Wang Yifeng Wang Mohammad Nazmul Hasan Lijie Gu Yung Dai Clayton Yanhong Du Cheng Chen Jacob E. Friedman Shelly C. Lu Wen-Xing Ding Tiangang Li |
| author_sort | David Matye |
| collection | DOAJ |
| description | Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfuration to maintain hepatic cysteine, coenzyme-A and glutathione availability. |
| first_indexed | 2024-04-12T12:07:55Z |
| format | Article |
| id | doaj.art-52ea7c8d29184987a1cfd046310b0ed5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T12:07:55Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-52ea7c8d29184987a1cfd046310b0ed52022-12-22T03:33:40ZengNature PortfolioNature Communications2041-17232022-09-0113111510.1038/s41467-022-33465-9TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasisDavid Matye0Sumedha Gunewardena1Jianglei Chen2Huaiwen Wang3Yifeng Wang4Mohammad Nazmul Hasan5Lijie Gu6Yung Dai Clayton7Yanhong Du8Cheng Chen9Jacob E. Friedman10Shelly C. Lu11Wen-Xing Ding12Tiangang Li13Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterDepartment of Cell Biology and Physiology, University of Kansas Medical CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterLaboratory for Molecular Biology and Cytometry Research, University of Oklahoma Health Sciences CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterKarsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterMatye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfuration to maintain hepatic cysteine, coenzyme-A and glutathione availability.https://doi.org/10.1038/s41467-022-33465-9 |
| spellingShingle | David Matye Sumedha Gunewardena Jianglei Chen Huaiwen Wang Yifeng Wang Mohammad Nazmul Hasan Lijie Gu Yung Dai Clayton Yanhong Du Cheng Chen Jacob E. Friedman Shelly C. Lu Wen-Xing Ding Tiangang Li TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis Nature Communications |
| title | TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis |
| title_full | TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis |
| title_fullStr | TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis |
| title_full_unstemmed | TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis |
| title_short | TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis |
| title_sort | tfeb regulates sulfur amino acid and coenzyme a metabolism to support hepatic metabolic adaptation and redox homeostasis |
| url | https://doi.org/10.1038/s41467-022-33465-9 |
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