Cobalt protoporphyrin IX increases endogenous G‐CSF and mobilizes HSC and granulocytes to the blood

Cobalt protoporphyrin IX increases endogenous G‐CSF and mobilizes HSC and granulocytes to the blood

Abstract Granulocyte colony‐stimulating factor (G‐CSF) is used in clinical practice to mobilize cells from the bone marrow to the blood; however, it is not always effective. We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G‐CSF, IL‐6, and MCP‐1 in mice, triggering the...

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Bibliographic Details
Main Authors: Agata Szade, Krzysztof Szade, Witold N Nowak, Karolina Bukowska‐Strakova, Lucie Muchova, Monika Gońka, Monika Żukowska, Maciej Cieśla, Neli Kachamakova‐Trojanowska, Marzena Rams‐Baron, Alicja Ratuszna, Józef Dulak, Alicja Józkowicz
Format: Article
Language:English
Published: Springer Nature 2019-11-01
Series:EMBO Molecular Medicine
Subjects:
CoPP
granulocyte colony‐stimulating factor
hematopoietic stem and progenitor cells
HO‐1
mobilization
Online Access:https://doi.org/10.15252/emmm.201809571

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