Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation
Summary: Circadian protein oscillations are maintained by the lifelong repetition of protein production and degradation in daily balance. It comes at the cost of ever-replayed, futile protein synthesis each day. This biosynthetic cost with a given oscillatory protein profile is relievable by a rhyth...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221006945 |
| _version_ | 1818640509651910656 |
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| author | Roktaek Lim Junghun Chae David E. Somers Cheol-Min Ghim Pan-Jun Kim |
| author_facet | Roktaek Lim Junghun Chae David E. Somers Cheol-Min Ghim Pan-Jun Kim |
| author_sort | Roktaek Lim |
| collection | DOAJ |
| description | Summary: Circadian protein oscillations are maintained by the lifelong repetition of protein production and degradation in daily balance. It comes at the cost of ever-replayed, futile protein synthesis each day. This biosynthetic cost with a given oscillatory protein profile is relievable by a rhythmic, not constant, degradation rate that selectively peaks at the right time of day but remains low elsewhere, saving much of the gross protein loss and of the replenishing protein synthesis. Here, our mathematical modeling reveals that the rhythmic degradation rate of proteins with circadian production spontaneously emerges under steady and limited activity of proteolytic mediators and does not necessarily require rhythmic post-translational regulation of previous focus. Additional (yet steady) post-translational modifications in a proteolytic pathway can further facilitate the degradation's rhythmicity in favor of the biosynthetic cost saving. Our work is supported by animal and plant circadian data, offering a generic mechanism for potentially widespread, time-dependent protein turnover. |
| first_indexed | 2024-12-16T23:12:24Z |
| format | Article |
| id | doaj.art-52f0267d2e9d4281a90a17d9d67d4cc6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-16T23:12:24Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-52f0267d2e9d4281a90a17d9d67d4cc62022-12-21T22:12:24ZengElsevieriScience2589-00422021-07-01247102726Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulationRoktaek Lim0Junghun Chae1David E. Somers2Cheol-Min Ghim3Pan-Jun Kim4Department of Biology, Hong Kong Baptist University, Kowloon, Hong KongDepartment of Physics, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of KoreaDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Center for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA; Arabidopsis Biological Resource Center, The Ohio State University, Columbus, OH 43210, USADepartment of Physics, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea; Corresponding authorDepartment of Biology, Hong Kong Baptist University, Kowloon, Hong Kong; Center for Quantitative Systems Biology & Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon, Hong Kong; State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon, Hong Kong; Abdus Salam International Centre for Theoretical Physics, 34151 Trieste, Italy; Corresponding authorSummary: Circadian protein oscillations are maintained by the lifelong repetition of protein production and degradation in daily balance. It comes at the cost of ever-replayed, futile protein synthesis each day. This biosynthetic cost with a given oscillatory protein profile is relievable by a rhythmic, not constant, degradation rate that selectively peaks at the right time of day but remains low elsewhere, saving much of the gross protein loss and of the replenishing protein synthesis. Here, our mathematical modeling reveals that the rhythmic degradation rate of proteins with circadian production spontaneously emerges under steady and limited activity of proteolytic mediators and does not necessarily require rhythmic post-translational regulation of previous focus. Additional (yet steady) post-translational modifications in a proteolytic pathway can further facilitate the degradation's rhythmicity in favor of the biosynthetic cost saving. Our work is supported by animal and plant circadian data, offering a generic mechanism for potentially widespread, time-dependent protein turnover.http://www.sciencedirect.com/science/article/pii/S2589004221006945Mathematical biosciencesSystems biologyIn silico biology |
| spellingShingle | Roktaek Lim Junghun Chae David E. Somers Cheol-Min Ghim Pan-Jun Kim Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation iScience Mathematical biosciences Systems biology In silico biology |
| title | Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation |
| title_full | Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation |
| title_fullStr | Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation |
| title_full_unstemmed | Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation |
| title_short | Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation |
| title_sort | cost effective circadian mechanism rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post translational regulation |
| topic | Mathematical biosciences Systems biology In silico biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221006945 |
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