Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients
Abstract Background In recent years, heart failure with preserved ejection fraction (HFpEF) has received increasing clinical attention. To investigate the diagnostic value of diastolic function parameters derived from planar gated blood-pool imaging (MUGA) for detecting HFpEF in coronary atheroscler...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03061-w |
| _version_ | 1797946082674606080 |
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| author | Qiaozhi Liu Shuaishuai Zhou Qi Wu Ronghua Zuo Shengjue Xiao Xiaotong Wang Ailin Liu Jie Liu Hong Zhu Defeng Pan |
| author_facet | Qiaozhi Liu Shuaishuai Zhou Qi Wu Ronghua Zuo Shengjue Xiao Xiaotong Wang Ailin Liu Jie Liu Hong Zhu Defeng Pan |
| author_sort | Qiaozhi Liu |
| collection | DOAJ |
| description | Abstract Background In recent years, heart failure with preserved ejection fraction (HFpEF) has received increasing clinical attention. To investigate the diagnostic value of diastolic function parameters derived from planar gated blood-pool imaging (MUGA) for detecting HFpEF in coronary atherosclerotic heart disease (coronary artery disease, CAD) patients. Methods Ninety-seven CAD patients with left ventricular ejection fraction ≥ 50% were included in the study. Based on the left ventricular end-diastolic pressure (LVEDP), the patients were divided into the HFpEF group (LVEDP ≥ 16 mmHg, 47 cases) and the normal LV diastolic function group (LVEDP < 16 mmHg, 50 cases). Diastolic function parameters obtained by planar MUGA include peak filling rate (PFR), filling fraction during the first third of diastole (1/3FF), filling rate during the first third of diastole (1/3FR), mean filling rate during diastole (MFR), and peak filling time (TPF). Echocardiographic parameters include left atrial volume index (LAVI), peak tricuspid regurgitation velocity (peak TR velocity), transmitral diastolic early peak inflow velocity (E), average early diastolic velocities of mitral annulars (average e′), average E/e′ ratio. The diastolic function parameters obtained by planar MUGA were compared with those obtained by echocardiography to explore the clinical value of planar MUGA for detecting HFpEF. Results The Receiver-operating characteristic curve analysis of diastolic function parameters obtained from planar MUGA and echocardiography to detect HFpEF showed that: among the parameters examined by planar MUGA, the area under the curve (AUC) of PFR, 1/3FF, 1/3FR, MFR and TPF were 0.827, 0.662, 0.653, 0.663 and 0.809, respectively. Among the echocardiographic parameters, the AUCs for average e′, average E/e′ ratio, peak TR velocity, and LAVI values were 0.747, 0.706, 0.735, and 0.633. The combination of PFR and TPF showed an AUC of 0.856. PFR combined with TPF value demonstrated better predictive value than average e′ (Z = 2.020, P = 0.043). Conclusion Diastolic function parameters obtained by planar MUGA can be used to diagnose HFpEF in CAD patients. PFR combined with TPF was superior to the parameters obtained by echocardiography and showed good sensitivity and predictive power for detecting HFpEF. |
| first_indexed | 2024-04-10T21:05:15Z |
| format | Article |
| id | doaj.art-52f07125df924aa8a904b88a2870c0cd |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-10T21:05:15Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-52f07125df924aa8a904b88a2870c0cd2023-01-22T12:04:09ZengBMCBMC Cardiovascular Disorders1471-22612023-01-0123111010.1186/s12872-023-03061-wDiagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patientsQiaozhi Liu0Shuaishuai Zhou1Qi Wu2Ronghua Zuo3Shengjue Xiao4Xiaotong Wang5Ailin Liu6Jie Liu7Hong Zhu8Defeng Pan9Department of Cardiology, Zaozhuang Municipal HospitalDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiology, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Cardiology, The Affiliated Hospital of Xuzhou Medical UniversityAbstract Background In recent years, heart failure with preserved ejection fraction (HFpEF) has received increasing clinical attention. To investigate the diagnostic value of diastolic function parameters derived from planar gated blood-pool imaging (MUGA) for detecting HFpEF in coronary atherosclerotic heart disease (coronary artery disease, CAD) patients. Methods Ninety-seven CAD patients with left ventricular ejection fraction ≥ 50% were included in the study. Based on the left ventricular end-diastolic pressure (LVEDP), the patients were divided into the HFpEF group (LVEDP ≥ 16 mmHg, 47 cases) and the normal LV diastolic function group (LVEDP < 16 mmHg, 50 cases). Diastolic function parameters obtained by planar MUGA include peak filling rate (PFR), filling fraction during the first third of diastole (1/3FF), filling rate during the first third of diastole (1/3FR), mean filling rate during diastole (MFR), and peak filling time (TPF). Echocardiographic parameters include left atrial volume index (LAVI), peak tricuspid regurgitation velocity (peak TR velocity), transmitral diastolic early peak inflow velocity (E), average early diastolic velocities of mitral annulars (average e′), average E/e′ ratio. The diastolic function parameters obtained by planar MUGA were compared with those obtained by echocardiography to explore the clinical value of planar MUGA for detecting HFpEF. Results The Receiver-operating characteristic curve analysis of diastolic function parameters obtained from planar MUGA and echocardiography to detect HFpEF showed that: among the parameters examined by planar MUGA, the area under the curve (AUC) of PFR, 1/3FF, 1/3FR, MFR and TPF were 0.827, 0.662, 0.653, 0.663 and 0.809, respectively. Among the echocardiographic parameters, the AUCs for average e′, average E/e′ ratio, peak TR velocity, and LAVI values were 0.747, 0.706, 0.735, and 0.633. The combination of PFR and TPF showed an AUC of 0.856. PFR combined with TPF value demonstrated better predictive value than average e′ (Z = 2.020, P = 0.043). Conclusion Diastolic function parameters obtained by planar MUGA can be used to diagnose HFpEF in CAD patients. PFR combined with TPF was superior to the parameters obtained by echocardiography and showed good sensitivity and predictive power for detecting HFpEF.https://doi.org/10.1186/s12872-023-03061-wPlanar gated blood-pool imagingHeart failure with preserved ejection fractionEchocardiographyCoronary artery diseaseLeft ventricular end-diastolic pressure |
| spellingShingle | Qiaozhi Liu Shuaishuai Zhou Qi Wu Ronghua Zuo Shengjue Xiao Xiaotong Wang Ailin Liu Jie Liu Hong Zhu Defeng Pan Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients BMC Cardiovascular Disorders Planar gated blood-pool imaging Heart failure with preserved ejection fraction Echocardiography Coronary artery disease Left ventricular end-diastolic pressure |
| title | Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients |
| title_full | Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients |
| title_fullStr | Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients |
| title_full_unstemmed | Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients |
| title_short | Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients |
| title_sort | diagnostic value of parameters derived from planar muga for detecting hfpef in coronary artery disease patients |
| topic | Planar gated blood-pool imaging Heart failure with preserved ejection fraction Echocardiography Coronary artery disease Left ventricular end-diastolic pressure |
| url | https://doi.org/10.1186/s12872-023-03061-w |
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