The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration)
The present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone,...
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| Format: | Article |
| Language: | Arabic |
| Published: |
University of Mosul, College of Veterinary Medicine
2019-09-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_162910_719f28493afa8ab20883c9a10f1c72dd.pdf |
| _version_ | 1818997299231064064 |
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| author | Saif Al-Jammas ayad Al-Sarraj |
| author_facet | Saif Al-Jammas ayad Al-Sarraj |
| author_sort | Saif Al-Jammas |
| collection | DOAJ |
| description | The present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological changes represented by renal tubular necrosis, glomerular atrophy and enlarged urinary spaces (widening of Bowman’s spaces), infiltration of lymphocytes and macrophages within interstitium of the cortex, formation of hyaline cast in some of the tubular lumens as well as fibrosis and hemorrhage in the cortex were also observed. While the group that received a protective (800 IU of vitamin E) prior to each Cytarabine injection showed a significant improvement that represented by focal regions in the cortex with a normal renal tubules except for a cloudy cell swelling which is a reversible injury, also neither cortical hemorrhage nor hyaline cast formation were seen, in addition to presence of focal areas of normal glomeruli. The present study suggests that vitamin E is an effective chemo-protective agent against nephrotoxicity when used prior to each Cytarabine administration. |
| first_indexed | 2024-12-20T21:43:25Z |
| format | Article |
| id | doaj.art-52f0848bbffb423dbe26b8b7de74b64f |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-20T21:43:25Z |
| publishDate | 2019-09-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-52f0848bbffb423dbe26b8b7de74b64f2022-12-21T19:25:44ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552019-09-0133231131610.33899/ijvs.2019.162910162910The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration)Saif Al-Jammas0ayad Al-Sarraj1College of Dentistry, University of Mosul, Mosul, IraqDental Basic Sciences- College of Dentistry- University of Mosul, Mosul, IraqThe present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological changes represented by renal tubular necrosis, glomerular atrophy and enlarged urinary spaces (widening of Bowman’s spaces), infiltration of lymphocytes and macrophages within interstitium of the cortex, formation of hyaline cast in some of the tubular lumens as well as fibrosis and hemorrhage in the cortex were also observed. While the group that received a protective (800 IU of vitamin E) prior to each Cytarabine injection showed a significant improvement that represented by focal regions in the cortex with a normal renal tubules except for a cloudy cell swelling which is a reversible injury, also neither cortical hemorrhage nor hyaline cast formation were seen, in addition to presence of focal areas of normal glomeruli. The present study suggests that vitamin E is an effective chemo-protective agent against nephrotoxicity when used prior to each Cytarabine administration.https://vetmedmosul.com/article_162910_719f28493afa8ab20883c9a10f1c72dd.pdfcytarabinerabbit's kidneyvitamin e |
| spellingShingle | Saif Al-Jammas ayad Al-Sarraj The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) Iraqi Journal of Veterinary Sciences cytarabine rabbit's kidney vitamin e |
| title | The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) |
| title_full | The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) |
| title_fullStr | The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) |
| title_full_unstemmed | The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) |
| title_short | The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration) |
| title_sort | histological changes induced by cytarabine on rabbits kidneys with and without vitamin e administration |
| topic | cytarabine rabbit's kidney vitamin e |
| url | https://vetmedmosul.com/article_162910_719f28493afa8ab20883c9a10f1c72dd.pdf |
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