Profile of conbercept in the treatment of neovascular age-related macular degeneration
Xinmin Lu,1 Xiaodong Sun1–31Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Eye Research Institute of Shanghai Jiao Tong University, Shanghai, People’s Rep...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-04-01
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| Series: | Drug Design, Development and Therapy |
| Online Access: | http://www.dovepress.com/profile-of-conbercept-in-the-treatment-ofnbspneovascular-age-related-m-peer-reviewed-article-DDDT |
| _version_ | 1811217134013906944 |
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| author | Lu XM Sun XD |
| author_facet | Lu XM Sun XD |
| author_sort | Lu XM |
| collection | DOAJ |
| description | Xinmin Lu,1 Xiaodong Sun1–31Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Eye Research Institute of Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Fundus Disease, Shanghai, People’s Republic of China Abstract: In developed countries, age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over the age of 65 years. Vascular endothelial growth factor (VEGF) plays a vital role in the formation of neovascular AMD. VEGF regulates angiogenesis, enhances vascular permeability, and drives the formation of choroidal neovascularization. As a result of the introduction of anti-VEGF drugs, the incidence of blindness from neovascular AMD has greatly reduced. Anti-VEGF drugs are used as a first-line treatment for neovascular AMD. The most recent anti-VEGF drug is conbercept, also named KH902, which was approved for the treatment of neovascular AMD by the China Food and Drug Administration in December 2013. In this review, recent clinical information regarding the use of conbercept to treat neovascular AMD is summarized. Conbercept is a soluble receptor decoy that blocks all isoforms of VEGF-A, VEGF-B, VEGF-C, and PlGF, which has a high binding affinity to VEGF and a long half-life in vitreous. Preclinical studies have demonstrated its anti-angiogenesis activity in both ocular neovascular disease models and tumor models. Clinical trials of conbercept have shown its superior efficacy and safety. Patients respond well even with 3-month treatment intervals following loading doses once a month for 3 months. The potential therapeutic effect of conbercept on the treatment of polypoidal choroidal vasculopathy, a special type of neovascular AMD, is also promising. In summary, conbercept is a new treatment option for ophthalmologists and their patients and may help address the limitations of current anti-VEGF drugs.Keywords: conbercept, KH902, age-related macular degeneration, vascular endothelial growth factor, neovascularization |
| first_indexed | 2024-04-12T06:50:14Z |
| format | Article |
| id | doaj.art-52f1da8d68414abaabe318fa3bd177c9 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-12T06:50:14Z |
| publishDate | 2015-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-52f1da8d68414abaabe318fa3bd177c92022-12-22T03:43:23ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-04-012015default2311232021443Profile of conbercept in the treatment of neovascular age-related macular degenerationLu XMSun XDXinmin Lu,1 Xiaodong Sun1–31Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Eye Research Institute of Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Fundus Disease, Shanghai, People’s Republic of China Abstract: In developed countries, age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over the age of 65 years. Vascular endothelial growth factor (VEGF) plays a vital role in the formation of neovascular AMD. VEGF regulates angiogenesis, enhances vascular permeability, and drives the formation of choroidal neovascularization. As a result of the introduction of anti-VEGF drugs, the incidence of blindness from neovascular AMD has greatly reduced. Anti-VEGF drugs are used as a first-line treatment for neovascular AMD. The most recent anti-VEGF drug is conbercept, also named KH902, which was approved for the treatment of neovascular AMD by the China Food and Drug Administration in December 2013. In this review, recent clinical information regarding the use of conbercept to treat neovascular AMD is summarized. Conbercept is a soluble receptor decoy that blocks all isoforms of VEGF-A, VEGF-B, VEGF-C, and PlGF, which has a high binding affinity to VEGF and a long half-life in vitreous. Preclinical studies have demonstrated its anti-angiogenesis activity in both ocular neovascular disease models and tumor models. Clinical trials of conbercept have shown its superior efficacy and safety. Patients respond well even with 3-month treatment intervals following loading doses once a month for 3 months. The potential therapeutic effect of conbercept on the treatment of polypoidal choroidal vasculopathy, a special type of neovascular AMD, is also promising. In summary, conbercept is a new treatment option for ophthalmologists and their patients and may help address the limitations of current anti-VEGF drugs.Keywords: conbercept, KH902, age-related macular degeneration, vascular endothelial growth factor, neovascularizationhttp://www.dovepress.com/profile-of-conbercept-in-the-treatment-ofnbspneovascular-age-related-m-peer-reviewed-article-DDDT |
| spellingShingle | Lu XM Sun XD Profile of conbercept in the treatment of neovascular age-related macular degeneration Drug Design, Development and Therapy |
| title | Profile of conbercept in the treatment of neovascular age-related macular degeneration |
| title_full | Profile of conbercept in the treatment of neovascular age-related macular degeneration |
| title_fullStr | Profile of conbercept in the treatment of neovascular age-related macular degeneration |
| title_full_unstemmed | Profile of conbercept in the treatment of neovascular age-related macular degeneration |
| title_short | Profile of conbercept in the treatment of neovascular age-related macular degeneration |
| title_sort | profile of conbercept in the treatment of nbsp neovascular age related macular degeneration |
| url | http://www.dovepress.com/profile-of-conbercept-in-the-treatment-ofnbspneovascular-age-related-m-peer-reviewed-article-DDDT |
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