GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT
Recent advances have come to suggest that connexins (Cxs), the core gap junction (GJs) and hemichannels (HCs) composing proteins, play a crucial role in neurodegenerative and neuroprotective conditions. GJs and HCs syncytia in the complex neuroglial network allows glial cells to support and even mod...
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| Format: | Article |
| Language: | English |
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Associazione Italiana Giovani Medici
2020-04-01
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| Series: | Euromediterranean Biomedical Journal |
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| Online Access: | http://www.embj.org/wp-content/uploads/2020/04/Vicario_07.pdf |
| _version_ | 1818212427797364736 |
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| author | Nunzio Vicario |
| author_facet | Nunzio Vicario |
| author_sort | Nunzio Vicario |
| collection | DOAJ |
| description | Recent advances have come to suggest that connexins (Cxs), the core gap junction (GJs) and hemichannels (HCs) composing proteins, play a crucial role in neurodegenerative and neuroprotective conditions. GJs and HCs syncytia in the complex neuroglial network allows glial cells to support and even modulate neuronal function in both physiological and pathological conditions. In this review we aim at reviewing the current knowledge in the context of neuroglial crosstalk and neurovascular units (NVU) and at delivering up-to-date insights on cell populations interplay in physiological and pathological central nervous system (CNS) conditions. |
| first_indexed | 2024-12-12T05:48:14Z |
| format | Article |
| id | doaj.art-52f451e15c0f41eca55b1b61a3271b91 |
| institution | Directory Open Access Journal |
| issn | 2279-7165 2279-7165 |
| language | English |
| last_indexed | 2024-12-12T05:48:14Z |
| publishDate | 2020-04-01 |
| publisher | Associazione Italiana Giovani Medici |
| record_format | Article |
| series | Euromediterranean Biomedical Journal |
| spelling | doaj.art-52f451e15c0f41eca55b1b61a3271b912022-12-22T00:35:45ZengAssociazione Italiana Giovani MediciEuromediterranean Biomedical Journal2279-71652279-71652020-04-01157313510.3269/1970-5492.2020.15.7GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNITNunzio Vicario0https://orcid.org/0000-0001-5934-3962University of CataniaRecent advances have come to suggest that connexins (Cxs), the core gap junction (GJs) and hemichannels (HCs) composing proteins, play a crucial role in neurodegenerative and neuroprotective conditions. GJs and HCs syncytia in the complex neuroglial network allows glial cells to support and even modulate neuronal function in both physiological and pathological conditions. In this review we aim at reviewing the current knowledge in the context of neuroglial crosstalk and neurovascular units (NVU) and at delivering up-to-date insights on cell populations interplay in physiological and pathological central nervous system (CNS) conditions.http://www.embj.org/wp-content/uploads/2020/04/Vicario_07.pdfneuroglial axisnvu cross-talkintercellular communicationastrocytesendothelial cellsneurodegeneration |
| spellingShingle | Nunzio Vicario GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT Euromediterranean Biomedical Journal neuroglial axis nvu cross-talk intercellular communication astrocytes endothelial cells neurodegeneration |
| title | GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT |
| title_full | GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT |
| title_fullStr | GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT |
| title_full_unstemmed | GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT |
| title_short | GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT |
| title_sort | gap junctions hemichannels and connexins and their role in the neurovascular unit |
| topic | neuroglial axis nvu cross-talk intercellular communication astrocytes endothelial cells neurodegeneration |
| url | http://www.embj.org/wp-content/uploads/2020/04/Vicario_07.pdf |
| work_keys_str_mv | AT nunziovicario gapjunctionshemichannelsandconnexinsandtheirroleintheneurovascularunit |