Genomic alterations in the F8 gene correlating with severe hemophilia A in Egyptian patients

Genomic alterations in the F8 gene correlating with severe hemophilia A in Egyptian patients

Abstract Background Hemophilia A (HA) is an inherited X‐linked recessive coagulation disorder caused by factor VIII (F8) deficiency. F8 rearrangements involving intron 22 (int22) and intron 1 (int1) account for almost half of severe HA phenotype also a hotspot exon 14 provides numerous mutational pa...

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Bibliographic Details
Main Authors: Rehab M. Mosaad, Khalda S. Amr, Eman A. Rabie, Naglaa O. Mostafa, Sonia A. Habib, Ghada Y. El‐Kamah
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
FVIII protein
hemophilia A
human F8 gene
mutation
nonsense
Online Access:https://doi.org/10.1002/mgg3.1575

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