Recent advances in smart‐responsive hydrogels for tissue repairing
Abstract The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart‐responsive hydrogels are three‐dimensional network structures formed by cross‐linking of hydrophilic polymers. In...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | MedComm – Biomaterials and Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mba2.23 |
| _version_ | 1811166455829364736 |
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| author | Cheng Hu Li Yang Yunbing Wang |
| author_facet | Cheng Hu Li Yang Yunbing Wang |
| author_sort | Cheng Hu |
| collection | DOAJ |
| description | Abstract The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart‐responsive hydrogels are three‐dimensional network structures formed by cross‐linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart‐responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart‐responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart‐responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart‐responsive hydrogels in tissue repair. In general, the current progress in the application of smart‐responsive hydrogels in tissue repair lays the foundation for future applications in other diseases. |
| first_indexed | 2024-04-10T15:52:41Z |
| format | Article |
| id | doaj.art-52f7de6b05654492a06ddcab76a647dc |
| institution | Directory Open Access Journal |
| issn | 2769-643X |
| language | English |
| last_indexed | 2024-04-10T15:52:41Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj.art-52f7de6b05654492a06ddcab76a647dc2023-02-10T23:20:05ZengWileyMedComm – Biomaterials and Applications2769-643X2022-09-0112n/an/a10.1002/mba2.23Recent advances in smart‐responsive hydrogels for tissue repairingCheng Hu0Li Yang1Yunbing Wang2National Engineering Research Center for Biomaterials, College of Biomedical Engineering Sichuan University Chengdu People's Republic of ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering Sichuan University Chengdu People's Republic of ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering Sichuan University Chengdu People's Republic of ChinaAbstract The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart‐responsive hydrogels are three‐dimensional network structures formed by cross‐linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart‐responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart‐responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart‐responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart‐responsive hydrogels in tissue repair. In general, the current progress in the application of smart‐responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.https://doi.org/10.1002/mba2.23drug deliverysmart‐responsive hydrogelstissue repair |
| spellingShingle | Cheng Hu Li Yang Yunbing Wang Recent advances in smart‐responsive hydrogels for tissue repairing MedComm – Biomaterials and Applications drug delivery smart‐responsive hydrogels tissue repair |
| title | Recent advances in smart‐responsive hydrogels for tissue repairing |
| title_full | Recent advances in smart‐responsive hydrogels for tissue repairing |
| title_fullStr | Recent advances in smart‐responsive hydrogels for tissue repairing |
| title_full_unstemmed | Recent advances in smart‐responsive hydrogels for tissue repairing |
| title_short | Recent advances in smart‐responsive hydrogels for tissue repairing |
| title_sort | recent advances in smart responsive hydrogels for tissue repairing |
| topic | drug delivery smart‐responsive hydrogels tissue repair |
| url | https://doi.org/10.1002/mba2.23 |
| work_keys_str_mv | AT chenghu recentadvancesinsmartresponsivehydrogelsfortissuerepairing AT liyang recentadvancesinsmartresponsivehydrogelsfortissuerepairing AT yunbingwang recentadvancesinsmartresponsivehydrogelsfortissuerepairing |