Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials
There is much research on nanomaterial from natural polymer because of its biocompatibility, abundance, and non-toxicity. This work is devoted to the study of free radical scavenging activities (FRSA) of nanoscale lignin biomaterials, which are recognized as promising natural antioxidants. The nanos...
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| Format: | Article |
| Language: | English |
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North Carolina State University
2014-09-01
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| Series: | BioResources |
| Subjects: | |
| Online Access: | http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_09_4_6699_Ge_Free_Radical_Scavenging_Lignin |
| _version_ | 1818538255498346496 |
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| author | Yuanyuan Ge Qiang Wei Zhili Li |
| author_facet | Yuanyuan Ge Qiang Wei Zhili Li |
| author_sort | Yuanyuan Ge |
| collection | DOAJ |
| description | There is much research on nanomaterial from natural polymer because of its biocompatibility, abundance, and non-toxicity. This work is devoted to the study of free radical scavenging activities (FRSA) of nanoscale lignin biomaterials, which are recognized as promising natural antioxidants. The nanoscale lignin biomaterials were prepared from alkaline lignin by a solution-precipitation method with either ethylene glycol (NL1) or alkaline solution (NL2). Structural analysis of the nanoscale lignin biomaterials were conducted by Scanning electron microscopy (SEM), laser particle size analyzer, Fourier transform-infrared spectroscopy (FT-IR), potentiometric titration, and gel permeation chromatography (GPC). The results indicated that NL2 had a smaller average particle size (278±13 nm) than NL1 (375±18 nm) and contained more phenolic hydroxyl groups (2.35±0.11 mmol/g) and had a lower weight-average molecular weight (Mw=6510±320). The FRSA of the biomaterials towards hydroxyl free radicals were measured and compared with the alkaline lignin. Some structure-activity relationships were proposed based on the analysis of experiment data, which revealed NL2 (IC50=0.18±0.01 mg/mL) had a 3.33 fold higher activity than NL1 (IC50=0.60±0.05 mg/mL), which could be attributed to the smaller particle size, more phenolic hydroxyl group, and lower weight-average molecular weight. |
| first_indexed | 2024-12-11T21:26:41Z |
| format | Article |
| id | doaj.art-52f8a651fe594ac89d4b411b080d6ac2 |
| institution | Directory Open Access Journal |
| issn | 1930-2126 1930-2126 |
| language | English |
| last_indexed | 2024-12-11T21:26:41Z |
| publishDate | 2014-09-01 |
| publisher | North Carolina State University |
| record_format | Article |
| series | BioResources |
| spelling | doaj.art-52f8a651fe594ac89d4b411b080d6ac22022-12-22T00:50:18ZengNorth Carolina State UniversityBioResources1930-21261930-21262014-09-01946699670610.15376/biores.9.4.6699-6706Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin BiomaterialsYuanyuan Ge0Qiang Wei1Zhili Li2School of Chemistry & Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning, 530004, China; ChinaSchool of Chemistry & Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning, 530004, China; ChinaGuangxi University; ChinaThere is much research on nanomaterial from natural polymer because of its biocompatibility, abundance, and non-toxicity. This work is devoted to the study of free radical scavenging activities (FRSA) of nanoscale lignin biomaterials, which are recognized as promising natural antioxidants. The nanoscale lignin biomaterials were prepared from alkaline lignin by a solution-precipitation method with either ethylene glycol (NL1) or alkaline solution (NL2). Structural analysis of the nanoscale lignin biomaterials were conducted by Scanning electron microscopy (SEM), laser particle size analyzer, Fourier transform-infrared spectroscopy (FT-IR), potentiometric titration, and gel permeation chromatography (GPC). The results indicated that NL2 had a smaller average particle size (278±13 nm) than NL1 (375±18 nm) and contained more phenolic hydroxyl groups (2.35±0.11 mmol/g) and had a lower weight-average molecular weight (Mw=6510±320). The FRSA of the biomaterials towards hydroxyl free radicals were measured and compared with the alkaline lignin. Some structure-activity relationships were proposed based on the analysis of experiment data, which revealed NL2 (IC50=0.18±0.01 mg/mL) had a 3.33 fold higher activity than NL1 (IC50=0.60±0.05 mg/mL), which could be attributed to the smaller particle size, more phenolic hydroxyl group, and lower weight-average molecular weight.http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_09_4_6699_Ge_Free_Radical_Scavenging_LigninNanomaterialLigninBiomaterialAntioxidantFree radical |
| spellingShingle | Yuanyuan Ge Qiang Wei Zhili Li Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials BioResources Nanomaterial Lignin Biomaterial Antioxidant Free radical |
| title | Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials |
| title_full | Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials |
| title_fullStr | Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials |
| title_full_unstemmed | Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials |
| title_short | Preparation and Evaluation of the Free Radical Scavenging Activities of Nanoscale Lignin Biomaterials |
| title_sort | preparation and evaluation of the free radical scavenging activities of nanoscale lignin biomaterials |
| topic | Nanomaterial Lignin Biomaterial Antioxidant Free radical |
| url | http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_09_4_6699_Ge_Free_Radical_Scavenging_Lignin |
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