Functional analysis of CTLA4 promoter variant and its possible implication in colorectal cancer immunotherapy

Functional analysis of CTLA4 promoter variant and its possible implication in colorectal cancer immunotherapy

BackgroundColorectal cancer (CRC) is a prevalent cancer, ranking as the third most common. Recent advances in our understanding of the molecular causes of this disease have highlighted the crucial role of tumor immune evasion in its initiation and progression. CTLA4, a receptor that acts as a negati...

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Bibliographic Details
Main Authors: Mariana Angulo-Aguado, Sarah Orjuela-Amarillo, Julián Francisco Mora-Jácome, Lea Paloma Córdoba, Antonio Gallego-Ortiz, Cristian Camilo Gaviria-Sabogal, Nora Contreras, Carlos Figueroa, Oscar Ortega-Recalde, Adrien Morel, Dora Janeth Fonseca-Mendoza
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Medicine
Subjects:
colorectal cancer
CTLA4
immune tumoral evasion
immunotherapy
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1160368/full

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