FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant wome...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1050 |
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| author | Karina dos Santos Eliane Lopes Rosado Ana Carolina Proença da Fonseca Gabriella Pinto Belfort Letícia Barbosa Gabriel da Silva Marcelo Ribeiro-Alves Verônica Marques Zembrzuski J. Alfredo Martínez Cláudia Saunders |
| author_facet | Karina dos Santos Eliane Lopes Rosado Ana Carolina Proença da Fonseca Gabriella Pinto Belfort Letícia Barbosa Gabriel da Silva Marcelo Ribeiro-Alves Verônica Marques Zembrzuski J. Alfredo Martínez Cláudia Saunders |
| author_sort | Karina dos Santos |
| collection | DOAJ |
| description | Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (<i>n</i> = 41) or DASH diet (<i>n</i> = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03–5.78; <i>p</i> = 0.04) and GG (aHR 3.91; CI 95% 1.12–13.70; <i>p</i> = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04–3.06; <i>p</i> = 0.02). |
| first_indexed | 2024-03-09T20:26:04Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:04Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-52f91ae6dc2049ca98cf9d67f3b060932023-11-23T23:33:45ZengMDPI AGNutrients2072-66432022-03-01145105010.3390/nu14051050FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic TrialKarina dos Santos0Eliane Lopes Rosado1Ana Carolina Proença da Fonseca2Gabriella Pinto Belfort3Letícia Barbosa Gabriel da Silva4Marcelo Ribeiro-Alves5Verônica Marques Zembrzuski6J. Alfredo Martínez7Cláudia Saunders8Programa de Pós-Graduação em Nutrição, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373-Bloco J 2° andar, Cidade Universitária, Rio de Janeiro 21941-902, BrazilPrograma de Pós-Graduação em Nutrição, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373-Bloco J 2° andar, Cidade Universitária, Rio de Janeiro 21941-902, BrazilLaboratório de Genética Humana, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Leônidas Deane, Avenida Brasil 4365, Rio de Janeiro 21040-360, BrazilPrograma de Pós-Graduação em Nutrição, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373-Bloco J 2° andar, Cidade Universitária, Rio de Janeiro 21941-902, BrazilPrograma de Pós-Graduação em Nutrição, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373-Bloco J 2° andar, Cidade Universitária, Rio de Janeiro 21941-902, BrazilInstituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil 4365, Rio de Janeiro 21040-360, BrazilLaboratório de Genética Humana, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Leônidas Deane, Avenida Brasil 4365, Rio de Janeiro 21040-360, BrazilPrecision Nutrition and Cardiometabolic Health Program, IMDEA Food Institute, Crta. de Canto Blanco, n 8, E-28049 Madrid, SpainPrograma de Pós-Graduação em Nutrição, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373-Bloco J 2° andar, Cidade Universitária, Rio de Janeiro 21941-902, BrazilExcessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (<i>n</i> = 41) or DASH diet (<i>n</i> = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03–5.78; <i>p</i> = 0.04) and GG (aHR 3.91; CI 95% 1.12–13.70; <i>p</i> = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04–3.06; <i>p</i> = 0.02).https://www.mdpi.com/2072-6643/14/5/1050gestational weight gainADRB2FTODASH dietdiabetes mellitusnutrigenetics |
| spellingShingle | Karina dos Santos Eliane Lopes Rosado Ana Carolina Proença da Fonseca Gabriella Pinto Belfort Letícia Barbosa Gabriel da Silva Marcelo Ribeiro-Alves Verônica Marques Zembrzuski J. Alfredo Martínez Cláudia Saunders FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial Nutrients gestational weight gain ADRB2 FTO DASH diet diabetes mellitus nutrigenetics |
| title | FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial |
| title_full | FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial |
| title_fullStr | FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial |
| title_full_unstemmed | FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial |
| title_short | FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial |
| title_sort | fto and adrb2 genetic polymorphisms are risk factors for earlier excessive gestational weight gain in pregnant women with pregestational diabetes mellitus results of a randomized nutrigenetic trial |
| topic | gestational weight gain ADRB2 FTO DASH diet diabetes mellitus nutrigenetics |
| url | https://www.mdpi.com/2072-6643/14/5/1050 |
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