Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience
Delayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). It is unclear whether fresh or frozen embryo transfer (FET) is the better option. We aimed to assess maternal and neonatal outcomes in patients having their first FET after a freeze-...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6395 |
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| author | Yao Chen Jianbo Zhou Yandong Chen Jihong Yang Yingying Hao Ting Feng Ruizhi Feng Yun Qian |
| author_facet | Yao Chen Jianbo Zhou Yandong Chen Jihong Yang Yingying Hao Ting Feng Ruizhi Feng Yun Qian |
| author_sort | Yao Chen |
| collection | DOAJ |
| description | Delayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). It is unclear whether fresh or frozen embryo transfer (FET) is the better option. We aimed to assess maternal and neonatal outcomes in patients having their first FET after a freeze-all cycle versus those having their first fresh embryo transfer (ET). We reviewed 720 women of AMA undergoing a first fresh ET (n = 375) or FET (n = 345) between January 2016 and April 2021. No significant difference in the live birth rate was found between FET and fresh ET (19.7% vs. 24.3%, <i>p</i> = 0.141). The clinical pregnancy rate was significantly lower in the FET group than in the fresh ET group (26.4 % (91/345) vs. 33.6% (126/375), <i>p</i> = 0.035), but FET resulted in higher birthweights (3217.16 ± 734.44 vs. 3003.37 ± 635.00, <i>p</i> = 0.037) and was associated with a lower incidence of preterm births (2.6% vs. 5.6%, <i>p</i> = 0.046). The risks of other maternal and neonatal outcomes did not differ significantly between the groups. Among women of AMA, the transfer of frozen embryos did not result in significantly higher rates of live birth than fresh embryos did; however, a freeze-all strategy may not be beneficial for the women of AMA. |
| first_indexed | 2024-03-09T18:57:36Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:36Z |
| publishDate | 2022-10-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-52f926d580f24d8681046c2ac832acb22023-11-24T05:16:59ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121639510.3390/jcm11216395Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center ExperienceYao Chen0Jianbo Zhou1Yandong Chen2Jihong Yang3Yingying Hao4Ting Feng5Ruizhi Feng6Yun Qian7Reproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaDepartment of Obstetrics and Gynecology, Binhai County People’s Hospital, Yancheng 224000, ChinaReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, ChinaReproductive Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, ChinaDelayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). It is unclear whether fresh or frozen embryo transfer (FET) is the better option. We aimed to assess maternal and neonatal outcomes in patients having their first FET after a freeze-all cycle versus those having their first fresh embryo transfer (ET). We reviewed 720 women of AMA undergoing a first fresh ET (n = 375) or FET (n = 345) between January 2016 and April 2021. No significant difference in the live birth rate was found between FET and fresh ET (19.7% vs. 24.3%, <i>p</i> = 0.141). The clinical pregnancy rate was significantly lower in the FET group than in the fresh ET group (26.4 % (91/345) vs. 33.6% (126/375), <i>p</i> = 0.035), but FET resulted in higher birthweights (3217.16 ± 734.44 vs. 3003.37 ± 635.00, <i>p</i> = 0.037) and was associated with a lower incidence of preterm births (2.6% vs. 5.6%, <i>p</i> = 0.046). The risks of other maternal and neonatal outcomes did not differ significantly between the groups. Among women of AMA, the transfer of frozen embryos did not result in significantly higher rates of live birth than fresh embryos did; however, a freeze-all strategy may not be beneficial for the women of AMA.https://www.mdpi.com/2077-0383/11/21/6395advanced maternal agefrozen embryo transferfresh embryo transferpregnancy outcomes |
| spellingShingle | Yao Chen Jianbo Zhou Yandong Chen Jihong Yang Yingying Hao Ting Feng Ruizhi Feng Yun Qian Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience Journal of Clinical Medicine advanced maternal age frozen embryo transfer fresh embryo transfer pregnancy outcomes |
| title | Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience |
| title_full | Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience |
| title_fullStr | Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience |
| title_full_unstemmed | Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience |
| title_short | Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience |
| title_sort | pregnancy outcomes after frozen embryo transfer and fresh embryo transfer in women of advanced maternal age single center experience |
| topic | advanced maternal age frozen embryo transfer fresh embryo transfer pregnancy outcomes |
| url | https://www.mdpi.com/2077-0383/11/21/6395 |
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