Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model
Periodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich...
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-04-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2022-0310 |
| _version_ | 1797832487632633856 |
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| author | Kocabas Rahim Yarkac Fatma Ucan Karabulut Ercan Keles Mert |
| author_facet | Kocabas Rahim Yarkac Fatma Ucan Karabulut Ercan Keles Mert |
| author_sort | Kocabas Rahim |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4–5 months old with a body weight of 275 ± 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases. |
| first_indexed | 2024-04-09T14:09:43Z |
| format | Article |
| id | doaj.art-52fa3013383844cab4a0899654d17d64 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-09T14:09:43Z |
| publishDate | 2023-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-52fa3013383844cab4a0899654d17d642023-05-06T15:31:53ZengDe GruyterOpen Chemistry2391-54202023-04-012111240610.1515/chem-2022-0310Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis modelKocabas Rahim0Yarkac Fatma Ucan1Karabulut Ercan2Keles Mert3Department of Biochemistry, Faculty of Medicine, Karamanoğlu Mehmetbey University, Karaman, TurkeyFaculty of Medicine, Faculty of Dentistry, Necmettin Erbakan University, Konya, TurkeyDepartment of Medical Pharmacology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, TurkeyFaculty of Medicine, Faculty of Dentistry, Lokman Hekim University, Ankara, TurkeyPeriodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4–5 months old with a body weight of 275 ± 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.https://doi.org/10.1515/chem-2022-0310experimental periodontitisykl-40moringa oleiferachitinase 3-like protein 1moringa tree |
| spellingShingle | Kocabas Rahim Yarkac Fatma Ucan Karabulut Ercan Keles Mert Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model Open Chemistry experimental periodontitis ykl-40 moringa oleifera chitinase 3-like protein 1 moringa tree |
| title | Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model |
| title_full | Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model |
| title_fullStr | Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model |
| title_full_unstemmed | Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model |
| title_short | Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model |
| title_sort | effect of moringa oleifera on serum ykl 40 level in vivo rat periodontitis model |
| topic | experimental periodontitis ykl-40 moringa oleifera chitinase 3-like protein 1 moringa tree |
| url | https://doi.org/10.1515/chem-2022-0310 |
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