Allergy-associated biomarkers in early life identified by Omics techniques
The prevalence and severity of allergic diseases have increased over the last 30 years. Understanding the mechanisms responsible for these diseases is a major challenge in current allergology, as it is crucial for the transition towards precision medicine, which encompasses predictive, preventive, a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2024.1359142/full |
| _version_ | 1797299752247754752 |
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| author | Elisa Zubeldia-Varela María Dolores Ibáñez-Sandín Cristina Gomez-Casado Marina Pérez-Gordo |
| author_facet | Elisa Zubeldia-Varela María Dolores Ibáñez-Sandín Cristina Gomez-Casado Marina Pérez-Gordo |
| author_sort | Elisa Zubeldia-Varela |
| collection | DOAJ |
| description | The prevalence and severity of allergic diseases have increased over the last 30 years. Understanding the mechanisms responsible for these diseases is a major challenge in current allergology, as it is crucial for the transition towards precision medicine, which encompasses predictive, preventive, and personalized strategies. The urge to identify predictive biomarkers of allergy at early stages of life is crucial, especially in the context of major allergic diseases such as food allergy and atopic dermatitis. Identifying these biomarkers could enhance our understanding of the immature immune responses, improve allergy handling at early ages and pave the way for preventive and therapeutic approaches. This minireview aims to explore the relevance of three biomarker categories (proteome, microbiome, and metabolome) in early life. First, levels of some proteins emerge as potential indicators of mucosal health and metabolic status in certain allergic diseases. Second, bacterial taxonomy provides insight into the composition of the microbiota through high-throughput sequencing methods. Finally, metabolites, representing the end products of bacterial and host metabolic activity, serve as early indicators of changes in microbiota and host metabolism. This information could help to develop an extensive identification of biomarkers in AD and FA and their potential in translational personalized medicine in early life. |
| first_indexed | 2024-03-07T22:55:14Z |
| format | Article |
| id | doaj.art-52fb8d10152c4795b47543a3426e1e87 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-03-07T22:55:14Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-52fb8d10152c4795b47543a3426e1e872024-02-23T04:34:42ZengFrontiers Media S.A.Frontiers in Allergy2673-61012024-02-01510.3389/falgy.2024.13591421359142Allergy-associated biomarkers in early life identified by Omics techniquesElisa Zubeldia-Varela0María Dolores Ibáñez-Sandín1Cristina Gomez-Casado2Marina Pérez-Gordo3Institute of Applied Molecular Medicine Nemesio Díez (IMMA), Department of Basic Medical Sciences, Facultad de Medicina. Universidad San Pablo-CEU, CEU Universities, Madrid, SpainDepartment of Allergy, H. Infantil Universitario Niño Jesús, FibHNJ, ARADyAL- RETICs Instituto de Salud Carlos III, IIS-P, Madrid, SpainDepartment of Dermatology, University Hospital Duesseldorf, Heinrich-Heine University, Duesseldorf, GermanyInstitute of Applied Molecular Medicine Nemesio Díez (IMMA), Department of Basic Medical Sciences, Facultad de Medicina. Universidad San Pablo-CEU, CEU Universities, Madrid, SpainThe prevalence and severity of allergic diseases have increased over the last 30 years. Understanding the mechanisms responsible for these diseases is a major challenge in current allergology, as it is crucial for the transition towards precision medicine, which encompasses predictive, preventive, and personalized strategies. The urge to identify predictive biomarkers of allergy at early stages of life is crucial, especially in the context of major allergic diseases such as food allergy and atopic dermatitis. Identifying these biomarkers could enhance our understanding of the immature immune responses, improve allergy handling at early ages and pave the way for preventive and therapeutic approaches. This minireview aims to explore the relevance of three biomarker categories (proteome, microbiome, and metabolome) in early life. First, levels of some proteins emerge as potential indicators of mucosal health and metabolic status in certain allergic diseases. Second, bacterial taxonomy provides insight into the composition of the microbiota through high-throughput sequencing methods. Finally, metabolites, representing the end products of bacterial and host metabolic activity, serve as early indicators of changes in microbiota and host metabolism. This information could help to develop an extensive identification of biomarkers in AD and FA and their potential in translational personalized medicine in early life.https://www.frontiersin.org/articles/10.3389/falgy.2024.1359142/fullatopyatopic dermatitisbiomarkersearly lifefood allergymetabolome |
| spellingShingle | Elisa Zubeldia-Varela María Dolores Ibáñez-Sandín Cristina Gomez-Casado Marina Pérez-Gordo Allergy-associated biomarkers in early life identified by Omics techniques Frontiers in Allergy atopy atopic dermatitis biomarkers early life food allergy metabolome |
| title | Allergy-associated biomarkers in early life identified by Omics techniques |
| title_full | Allergy-associated biomarkers in early life identified by Omics techniques |
| title_fullStr | Allergy-associated biomarkers in early life identified by Omics techniques |
| title_full_unstemmed | Allergy-associated biomarkers in early life identified by Omics techniques |
| title_short | Allergy-associated biomarkers in early life identified by Omics techniques |
| title_sort | allergy associated biomarkers in early life identified by omics techniques |
| topic | atopy atopic dermatitis biomarkers early life food allergy metabolome |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2024.1359142/full |
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