Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles
IntroductionChitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also with several disorders, including fibrosis, atherosclerosis, allergies, and cancer. However, CLP’s role in tumors is far from clear. MethodsHere, we utilize Drosophila melanogaster and molecula...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1170122/full |
| _version_ | 1797837903276015616 |
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| author | Dilan Khalili Martin Kunc Sarah Herbrich Anna M. Müller Ulrich Theopold |
| author_facet | Dilan Khalili Martin Kunc Sarah Herbrich Anna M. Müller Ulrich Theopold |
| author_sort | Dilan Khalili |
| collection | DOAJ |
| description | IntroductionChitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also with several disorders, including fibrosis, atherosclerosis, allergies, and cancer. However, CLP’s role in tumors is far from clear. MethodsHere, we utilize Drosophila melanogaster and molecular genetics to investigate the function of CLPs (imaginal disc growth factors; Idgf’s) in RasV12 dysplastic salivary glands. Results and discussionWe find one of the Idgf’s members, Idgf3, is transcriptionally induced in a JNK-dependent manner via a positive feedback loop mediated by reactive oxygen species (ROS). Moreover, Idgf3 accumulates in enlarged endosomal vesicles (EnVs) that promote tumor progression by disrupting cytoskeletal organization. The process is mediated via the downstream component, aSpectrin, which localizes to the EnVs. Our data provide new insight into CLP function in tumors and identifies specific targets for tumor control. |
| first_indexed | 2024-04-09T15:33:13Z |
| format | Article |
| id | doaj.art-52fc893ffaa1407981178991d5c60bff |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T15:33:13Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-52fc893ffaa1407981178991d5c60bff2023-04-28T04:59:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11701221170122Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesiclesDilan KhaliliMartin KuncSarah HerbrichAnna M. MüllerUlrich TheopoldIntroductionChitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also with several disorders, including fibrosis, atherosclerosis, allergies, and cancer. However, CLP’s role in tumors is far from clear. MethodsHere, we utilize Drosophila melanogaster and molecular genetics to investigate the function of CLPs (imaginal disc growth factors; Idgf’s) in RasV12 dysplastic salivary glands. Results and discussionWe find one of the Idgf’s members, Idgf3, is transcriptionally induced in a JNK-dependent manner via a positive feedback loop mediated by reactive oxygen species (ROS). Moreover, Idgf3 accumulates in enlarged endosomal vesicles (EnVs) that promote tumor progression by disrupting cytoskeletal organization. The process is mediated via the downstream component, aSpectrin, which localizes to the EnVs. Our data provide new insight into CLP function in tumors and identifies specific targets for tumor control.https://www.frontiersin.org/articles/10.3389/fonc.2023.1170122/fullDrosophilaimmunitytumorendosomal vesiclessalivary glandschitinase |
| spellingShingle | Dilan Khalili Martin Kunc Sarah Herbrich Anna M. Müller Ulrich Theopold Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles Frontiers in Oncology Drosophila immunity tumor endosomal vesicles salivary glands chitinase |
| title | Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| title_full | Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| title_fullStr | Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| title_full_unstemmed | Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| title_short | Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| title_sort | chitinase like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles |
| topic | Drosophila immunity tumor endosomal vesicles salivary glands chitinase |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1170122/full |
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