Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species

Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species

This review explores various methods for modulating protein stability to achieve target protein degradation, which is a crucial aspect in the study of biological processes and drug design. Thirty years have passed since the introduction of heat-inducible degron cells utilizing the N-end rule, and me...

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Bibliographic Details
Main Authors: Yoshitaka Ogawa, Taisei P. Ueda, Keisuke Obara, Kohei Nishimura, Takumi Kamura
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
target protein degradation
ubiquitin
ubiquitin proteasome pathway
E3 ubiquitin ligase
PROTACs
Online Access:https://www.mdpi.com/2073-4409/13/2/175

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