The use of phytogel with tincture of black alder leaves in experimental gingivitis
Objectives. To determine the dynamics of clinical and cytological parameters of the gingival mucosa in the treatment of experimental gingivitis with a phytopreparation based on black alder leaves tincture. Material and methods. The effectiveness of phytogel containing black alder leaves tincture wa...
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| Format: | Article |
| Language: | English |
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Vitebsk State Order of Peoples’ Friendship Medical University
2022-06-01
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| Series: | Вестник Витебского государственного медицинского университета |
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| Online Access: | https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_94-101.pdf |
| _version_ | 1811193479641956352 |
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| author | N.G. Krautsova-Kukhmar N.S. Gurina N.V. Shakavets T.V. Kidyasova |
| author_facet | N.G. Krautsova-Kukhmar N.S. Gurina N.V. Shakavets T.V. Kidyasova |
| author_sort | N.G. Krautsova-Kukhmar |
| collection | DOAJ |
| description | Objectives. To determine the dynamics of clinical and cytological parameters of the gingival mucosa in the treatment of experimental gingivitis with a phytopreparation based on black alder leaves tincture.
Material and methods. The effectiveness of phytogel containing black alder leaves tincture was evaluated on the model of experimental gingivitis caused in Wistar rats by injecting 0.2 ml of Vipraksin (an aqueous solution of the viper’s venom) into the submucosal layer of the gum. Phytogel and the comparison drug Metrogil Denta were applied 1 or 2 times a day with an interval of 8 hours during 2 (4) days in the corresponding groups.
Results and conclusion. The effectiveness of phytogel with alcohol extraction from the leaves of black alder in experimental gingivitis has been studied, depending on the frequency of use and duration of treatment.
It has been found out that the double use of phytogel containing black alder leaves tincture during 4 days in experimental gingivitis leads to the disappearance of clinical symptoms and complete restoration of the gum structure. With a similar scheme of using Metrogil Denta gel, clinical symptoms disappear, the basal layer of the gingival mucosa is restored, but the histological sign of an inflammation – intracellular edema of the epithelium of the spinous layer remains, which indicates the high effectiveness of the developed herbal preparation in experimental gingivitis. |
| first_indexed | 2024-04-12T00:10:24Z |
| format | Article |
| id | doaj.art-52fd014ec49b436e9dfcbd165694637e |
| institution | Directory Open Access Journal |
| issn | 1607-9906 2312-4156 |
| language | English |
| last_indexed | 2024-04-12T00:10:24Z |
| publishDate | 2022-06-01 |
| publisher | Vitebsk State Order of Peoples’ Friendship Medical University |
| record_format | Article |
| series | Вестник Витебского государственного медицинского университета |
| spelling | doaj.art-52fd014ec49b436e9dfcbd165694637e2022-12-22T03:55:59ZengVitebsk State Order of Peoples’ Friendship Medical UniversityВестник Витебского государственного медицинского университета1607-99062312-41562022-06-0121394101https://doi.org/10.22263/2312-4156.2022.3.94The use of phytogel with tincture of black alder leaves in experimental gingivitisN.G. Krautsova-Kukhmar0N.S. Gurina1N.V. Shakavets2https://orcid.org/0000-0002-8811-9545T.V. Kidyasova3Belarusian State Medical University, Minsk, Republic of BelarusBelarusian State Medical University, Minsk, Republic of BelarusBelarusian State Medical University, Minsk, Republic of BelarusBelarusian State Medical University, Minsk, Republic of BelarusObjectives. To determine the dynamics of clinical and cytological parameters of the gingival mucosa in the treatment of experimental gingivitis with a phytopreparation based on black alder leaves tincture. Material and methods. The effectiveness of phytogel containing black alder leaves tincture was evaluated on the model of experimental gingivitis caused in Wistar rats by injecting 0.2 ml of Vipraksin (an aqueous solution of the viper’s venom) into the submucosal layer of the gum. Phytogel and the comparison drug Metrogil Denta were applied 1 or 2 times a day with an interval of 8 hours during 2 (4) days in the corresponding groups. Results and conclusion. The effectiveness of phytogel with alcohol extraction from the leaves of black alder in experimental gingivitis has been studied, depending on the frequency of use and duration of treatment. It has been found out that the double use of phytogel containing black alder leaves tincture during 4 days in experimental gingivitis leads to the disappearance of clinical symptoms and complete restoration of the gum structure. With a similar scheme of using Metrogil Denta gel, clinical symptoms disappear, the basal layer of the gingival mucosa is restored, but the histological sign of an inflammation – intracellular edema of the epithelium of the spinous layer remains, which indicates the high effectiveness of the developed herbal preparation in experimental gingivitis.https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_94-101.pdfgingivitisphytogelblack alderinflammationhistological examination |
| spellingShingle | N.G. Krautsova-Kukhmar N.S. Gurina N.V. Shakavets T.V. Kidyasova The use of phytogel with tincture of black alder leaves in experimental gingivitis Вестник Витебского государственного медицинского университета gingivitis phytogel black alder inflammation histological examination |
| title | The use of phytogel with tincture of black alder leaves in experimental gingivitis |
| title_full | The use of phytogel with tincture of black alder leaves in experimental gingivitis |
| title_fullStr | The use of phytogel with tincture of black alder leaves in experimental gingivitis |
| title_full_unstemmed | The use of phytogel with tincture of black alder leaves in experimental gingivitis |
| title_short | The use of phytogel with tincture of black alder leaves in experimental gingivitis |
| title_sort | use of phytogel with tincture of black alder leaves in experimental gingivitis |
| topic | gingivitis phytogel black alder inflammation histological examination |
| url | https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_94-101.pdf |
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